Influence of body mass index on sagittal hip range of motion and gait speed recovery six months after total hip arthroplasty

ConclusionsAll patients, including obese patients, have significant functional improvement after THA, objectively assessed by gait speed. Even if patients did not fully recover to the level of a healthy control person after THA, functional gain is comparable irrespective of BMI.
Source: International Orthopaedics - Category: Orthopaedics Source Type: research

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Conclusions: OA-related models of cartilage stress reveal multiple mechanisms by which glutathione provides oxidative stress resistance and resilience. PMID: 31522568 [PubMed - as supplied by publisher]
Source: Connective Tissue Research - Category: Research Tags: Connect Tissue Res Source Type: research
Knee osteoarthritis (OA) is a highly prevalent condition. People with knee OA often have other co-morbidities such as obesity. Exercise is advocated in all clinical guidelines for the management of knee OA. It...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Study protocol Source Type: research
Abstract The increasing occurrence of obesity has become a significant public health concern. Obese individuals have higher prevalence of heart disease, stroke, osteoarthritis, diabetes, and reproductive disorders. Reproductive problems include menstrual irregularities, pregnancy complications, and infertility due to anovulation, in women, and lower testosterone and diminished sperm count, in men. In particular, obese women have reduced levels of both gonadotropin hormones and, in obese men, lower testosterone is accompanied by diminished luteinizing hormone. Together these findings indicate central dysregulation ...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
J Knee Surg DOI: 10.1055/s-0039-1696735Limited evidence is available on mid-term follow-up for patients with body mass index (BMI) ≥ 40 receiving a unicompartmental knee arthroplasty (UKA). The primary objective of this study was to investigate survival of the UKA in patients with BMI ≥ 40. Secondary objectives were to assess functional and patient reported outcome measures (PROMs). Survival analysis with endpoint revision of any component for any reason was conducted using Kaplan–Meier technique on 121 knees (103 patients) that underwent UKA with Oxford Phase 3 implant (Oxford Knee,...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This popular science piece on the development of senolytic therapies capable of clearing harmful senescent cells from aging tissues is a cut above the average. It is important to see more publicity for this line of work. Not because it will aid the industry, but because the more attention that is given to the field, the faster that existing senolytic treatments such as the dasatinib and quercetin combination will become available through off-label prescription and physician networks. Tens of millions of patients with inflammatory age-related diseases caused in part by senescent cells, and the many cancer survivors with hig...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ConclusionsLeg muscle asymmetry in men, irrespective of obesity, was associated with significantly higher grade of radiographic knee OA and prevalent knee pain. Longitudinal studies will be needed to determine the cause-and-effect relationship and to determine whether the higher or lower mass, beyond the asymmetry, is associated with radiographic severity or symptomatic knee OA.Key Points•Leg muscle asymmetry was related to prevalence and radiographic severity of knee OA, especially in men.•Leg muscle asymmetry was associated with knee pain.•Those with both leg muscle asymmetry and obesity showed higher prev...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Conclusions: Genicular nerve ablation with radiofrequency has demonstrated favorable outcomes with low complication rates.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Review Article Source Type: research
J Knee Surg DOI: 10.1055/s-0039-1695706Prostate cancer (PCa) is one of the most prevalent diseases in the North American elderly population. Moreover, many patients undergo prostate resection without further treatment and are often considered cured. As such, it is expected that many undergo total knee arthroplasty (TKA) for osteoarthritis while having a history of PCa. Nonetheless, limited research is available on this topic, and without it, surgeons may not be aware of increased complication rates. Therefore, the purpose of this study was to evaluate whether patients at a national level with a history of PCa are at increa...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
R Abstract The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the burden of OA and the need to define preventive and therapeutic interventions targeting the modifiable components of OA, ...
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research
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