How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network.

How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network. J Nephrol. 2019 Jan 02;: Authors: Eccher A, Lombardini L, Girolami I, Puoti F, Zaza G, Gambaro G, Carraro A, Valotto G, Cima L, Novelli L, Neil D, Montin U, Scarpa A, Brunelli M, Nanni Costa A, D'Errico A Abstract Guidelines for donor selection have changed to expand the donor pool, considering potential donors affected by a neoplasm. Aim of this retrospective study is to look at the use of organs from donors with a current or history of neoplasm within the Italian Transplant Network. Data, collected and validated by Italian National Health Institute for the time interval 2006-2015, have been reviewed retrospectively by mean of multivariable pivot tables. Donors with neoplasia represented about 5% of all donors, resulting in about 4% of all transplants. Donors presented a benign neoplasm in 29.08% of cases, a malignancy with variable risk of transmission in 69.75% while in 1.34% the nature of neoplasm could not be assessed. Considering all procedures, rate of transmission of a malignancy was 0.03% (10 cases) of all 29858 transplants of the time interval. Notably, cases of transmission were not from donors of this pool, but from donors that, according to our protocols, had no elements of suspect at time of donation. As recipient safety is always the priority and as guidelines have set exclusion criteria for donors with some spe...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research