Vision loss and 12-year risk of dementia in older adults: the 3C cohort study

This study is based on the Three-City (3C) study, a population-based cohort of 7736 initially dementia-f ree participants aged 65 years and over with 12 years of follow-up. Near visual impairment (VI) was measured and distance visual function (VF) loss was self-reported. Dementia was diagnosed and screened over the 12-year period. At baseline, 8.7% had mild near VI, 4.2% had moderate to severe near V I, and 5.3% had distance VF loss. Among the 882 dementia cases diagnosed over the 12-year follow-up period, 140 cases occurred in the first 2 years, 149 from 2 to 4 years and 593 beyond 4 years after inclusion. In Cox multivariate analysis, moderate to severe near VI was associated with an increa sed risk of dementia in the first 2 years (HR 2.0, 95% CI 1.2–3.3) and from 2 to 4 years (HR 1.8, 95% CI 1.1–3.1) but the association was not significant beyond 4 years after inclusion even if pointing in similar direction (HR 1.3, 95% CI 0.95–1.9). Mild near VI was associated with an increased risk of dementia only in the first 2 years (HR 1.6, 95% CI 1.1–2.5). Moreover, self-reported distance VF loss was associated with an increased risk beyond 4 years after inclusion (HR 1.5, 95% CI 1.1–2.0) but the association was no longer significant after taking into account bas eline cognitive performances. Further adjustment for engagement in cognitively stimulating activities only slightly decreased these associations. However, there was an interaction between visi...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research