What lessons can we learn from an apparent decrease in the use of topical drugs for psoriasis?

What lessons can we learn from an apparent decrease in the use of topical drugs for psoriasis? Br J Dermatol. 2019 Jan;180(1):19 Authors: Criado PR PMID: 30604540 [PubMed - in process]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Authors: Kong Y, Zhang S, Su X, Peng D, Su Y Abstract Background: YKL-40, also named chitinase-3-like protein 1, has been confirmed as an inflammatory glycoprotein associated with cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. Growing evidence have demonstrated that serum levels of YKL-40 in psoriatic patients were increased, however, the results were appearance contradictory among the current published studies. Methods: Research involved in serum levels of YKL-40 in psoriatic patients and healthy control individuals were searched in PUBMED, EMBASE and The Cochra...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
We present a case of E. rhusiopathiae mitral valve endocarditis in a farmer with psoriasis presented with acute intractable heart failure requiring valve replacement surgery. E. rhusiopathiae was identified by 16S rRNA-based gene sequencing from culture-negative, surgically excised mitral valve leaflets.
Source: IDCases - Category: Infectious Diseases Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Conditions:   Rheumatoid Arthritis;   Polyarticular Juvenile Idiopathic Arthritis;   Psoriatic Arthritis;   Ankylosing Spondylitis;   Crohn Disease;   Ulcerative Colitis;   Plaque Psoriasis;   Pediatric Plaque Psoriasis;   Pediatric Crohns Disease;   Hidradenitis Suppurativa;   Non-inf ectious Uveitis Intervention:   Drug: 40 mg MSB11022 Sponsors:   Fresenius Kabi SwissBioSim GmbH;   PRA Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, encapsulation of celastrol by niosomes increased the water-solubility and permeation of celastrol into the skin, significantly improving its anti-psoriasis activity in mice.Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Conditions:   Rheumatoid Arthritis;   Polyarticular Juvenile Idiopathic Arthritis;   Psoriatic Arthritis;   Ankylosing Spondylitis;   Crohn Disease;   Ulcerative Colitis;   Plaque Psoriasis;   Pediatric Plaque Psoriasis;   Pediatric Crohns Disease;   Hidradenitis Suppurativa;   Non-inf ectious Uveitis Intervention:   Drug: 40 mg MSB11022 Sponsors:   Fresenius Kabi SwissBioSim GmbH;   PRA Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Purpose of review Several chronic inflammatory skin disorders have been linked to metabolic syndrome (MetS) and an increased risk for cardiovascular disease. In this review, we will summarize the recent evidence on the association between psoriasis, hidradenitis suppurativa (HS), and atopic dermatitis (AD) and metabolic syndrome with careful attention to this association among the pediatric population. Recent findings Historically, psoriasis has exhibited the most robust association with MetS in the literature. Recent studies show that the prevalence of MetS appears to be higher among patients with HS and can be assoc...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: GENETICS OF VASCULAR MALFORMATION AND THERAPEUTIC IMPLICATIONS: Edited by Joyce M.C. Teng Source Type: research
(National Psoriasis Foundation) National Psoriasis Foundation awards over $2 million in grants and fellowships to enable the advancement of a cure for psoriatic disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The association between psoriasis and Parkinson ’s disease has not been established.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
This study evaluated the SDF-1/CXCL12 and soluble CXCR4 (sCXCR4) levels, and investigated their clinical relevance in adult-onset Still's disease (AOSD). METHODS: Forty-two AOSD patients and 30 healthy controls (HC) were enrolled for serum sampling. Expression levels of CXCL12 and CXCR4 in skin biopsy materials of 40 AOSD patients, 10 patients with eczema, or 10 psoriasis, and 10 HC skin were evaluated with immunohistochemistry. RESULTS: The serum CXCL12 levels in patients with AOSD (2,452±1,531 pg/mL) were higher than those in HC (1,708±1,322 pg/mL, p=0.017). The serum sCXCR4 levels in patients with ...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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