The multifaceted association between psoriasis and obesity.

The multifaceted association between psoriasis and obesity. Br J Dermatol. 2019 Jan;180(1):24 Authors: Gisondi P, Girolomoni G PMID: 30604555 [PubMed - in process]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Purpose of review Several chronic inflammatory skin disorders have been linked to metabolic syndrome (MetS) and an increased risk for cardiovascular disease. In this review, we will summarize the recent evidence on the association between psoriasis, hidradenitis suppurativa (HS), and atopic dermatitis (AD) and metabolic syndrome with careful attention to this association among the pediatric population. Recent findings Historically, psoriasis has exhibited the most robust association with MetS in the literature. Recent studies show that the prevalence of MetS appears to be higher among patients with HS and can be assoc...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: GENETICS OF VASCULAR MALFORMATION AND THERAPEUTIC IMPLICATIONS: Edited by Joyce M.C. Teng Source Type: research
ConclusionERAPSO revealed inadequate medical care of obese psoriasis participants with insufficient support for weight loss through diet or increased physical activity. Although psoriasis participants showed an intact self-perception of obesity, they seemed to lack intrinsic motivation to lose weight, highlighting the need for external support in losing weight via tailored programs. Since psoriasis severity correlates with impairment in diets and sports, treating psoriasis adequately may allow participants to follow weight loss programs more successfully.FundingNovartis Pharma GmbH, Nuremberg, DE.
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
This study included 21 non-obese patients with moderate psoriasis and 20 non-obese clinically healthy age and sex matched controls. Patients underwent 24 sessions of NB-UVB radiation. A 4 mm punch skin biopsy was taken from all patients before and after treatment and from the controls for estimation of tissue vaspin level by enzyme-linked immunosorbent assay. Vaspin levels was significantly lower in patients before NB-UVB (99. 72 pg/mg ± 12.11 pg/mg) compared to controls (257.34 pg/mg ± 28.11 pg/mg) with (P 
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
The end of another quarter means a new list of FDA-approved drugs for primary care. Which ones should you know about? Click through to find out.  
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Obesity Opioid Related Disorders Osteoporosis Pregnancy and Birth Psoriasis Rheumatoid Arthritis T2 Diabetes Source Type: news
ConclusionsOur findings show that ixekizumab is both effective and safe in the treatment of psoriasis in routine clinical practice.ResumenIntroducciónIxekizumab es un fármaco efectivo y seguro en el tratamiento de pacientes con psoriasis dentro de ensayos clínicos. Nuestro objetivo es valorar la eficacia y seguridad de ixekizumab en la práctica clínica habitual.MaterialEstudio retrospectivo incluyendo todos los pacientes que han recibido ixekizumab en 2 servicios de dermatología de la ciudad de Valencia.ResultadosSe incluyeron un total de 75 pacientes, siendo el 53,3% varones y el ...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Abstract BACKGROUND: Obesity is associated with psoriasis and negatively affects response to therapy. OBJECTIVE: To evaluate efficacy and safety of brodalumab in non-obese vs obese patients with psoriasis. METHODS: In this post hoc analysis of the prospective, phase 3, multicentre, randomized, placebo- and active comparator-controlled AMAGINE-2 and AMAGINE-3 trials, patients were randomized to treatment with brodalumab 210 mg every 2 weeks, ustekinumab, or placebo for a 12-week induction phase. At week 12, patients who received brodalumab 210 mg Q2W continued brodalumab, those treated with ustekinumab co...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Conclusion: Eruptive LP showed significant association with MS. Further studies with large sample size in each variant and control group are needed to confirm it which are the limitations in our study.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Obesity is a common cardiovascular risk factor in psoriatic disease. Although the prevalence of obesity is high, the factors associated with it in patients with psoriatic arthritis (PsA) are poorly understood. We aimed to analyze the frequency and obesity-associated factors in a cohort of PsA. This retrospective cross-sectional study included 290 consecutive patients with PsA according to CASPAR criteria. Three-hundred ten psoriatic patients without arthritis and 600 outpatients without inflammatory conditions were used as comparison populations. The factors associated with obesity were analyzed first using conditional lo...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
In conclusion, through activating the JAK2/STAT3 signaling pathway in liver and reducing the expression of SCOCS-3, CBX could further decrease the expressions of SREBP-1c, FAS and ameliorate the inflammatory state of liver, so as to protecting the liver from lipid metabolism damage induced by high-fat diet. Therefore, CBX has the possibility for the treatment of obesity, hyperlipidemia, and inflammation. PMID: 31261036 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
This article provides an update on the role of adipose tissues in psoriasis.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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