New Technique Could Be a Breakthrough for Motility Research

In this study, we showed a mitigation of these common problems with optogenetic muscle control,” said Hugh Herr, who led the research team and heads the Media Lab’s Biomechatronics group. “This has great promise for the development of solutions for patients suffering from debilitating conditions like muscle paralysis.” The group's research paper was published in the Dec. 13 issue of Nature Communications. Doctors already use electrical nerve stimulation to treat patients with spinal cord injury, and to improve muscle conditioning in people with muscular degenerative diseases. The downside of electrical stimulation is that it can quickly fatigue muscles and is difficult to target precisely. That's why scientists like Srinivasan and Maimon are looking for alternative methods of nerve stimulation. Optogenetic stimulation relies on nerves that have been genetically engineered to express light-sensitive algae proteins called opsins. These proteins control electrical signals such as nerve impulses — essentially, turning them on and off — when they are exposed to certain wavelengths of light. Using mice and rats engineered to express these opsins in two key nerves of the leg, the researchers were able to control the up and down movement of the rodents’ ankle joint by switching on an LED that was either attached over the skin or implant...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news

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Publication date: August 2019Source: Current Opinion in Behavioral Sciences, Volume 28Author(s): Bianka Karshikoff, Melissa Anne Tadros, Sean Mackey, Ihssane ZouikrToday’s treatment for chronic pain is inadequate, and novel targets need to be identified. This requires a better understanding of the mechanisms involved in pain sensitization and chronification. In this review, we discuss how peripheral inflammation, as occurs during an infection, modulates the central pain system. In rodents, neonatal inflammation leads to increased pain sensitivity in adulthood by priming immune components both peripherally and central...
Source: Current Opinion in Behavioral Sciences - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 20 March 2019Source: The Journal of Foot and Ankle SurgeryAuthor(s): J. Randolph Clements, Ajay K. GhaiAbstractDisruption of the plantar plate is a common cause of forefoot pain, metatarsalgia, and metatarsophalangeal joint malalignment. Although surgical repair of the plantar plate has improved, there has been no consensus on the clinical superiority of any single technique, or combination of techniques, described in the literature to date. In this publication, we report a case of plantar plate injury treated with an innovative new technique with 20-month follow-up.
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
We report a case of a 48-year-old female who presented four months following a low-energy trauma with symptoms most consistent with adhesive capsulitis. An MRI demonstrated extensive patchy areas of intramuscular edema-like signal involving the lateral head of the deltoid with associated muscle atrophy, in keeping with a subacute denervation injury. She was diagnosed with quadrilateral space syndrome (QSS) and successfully treated with an fluoroscopic-guided corticosteroid injection. At her two-year follow-up, the patient had regained full function and had no lasting symptoms. Non-specific symptoms like ill-defined shoulde...
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
In states that legalized medical marijuana, there was a 4.8 percent decrease in reported pain for conditions that qualified for pot treatment (cancer, arthritis, glaucoma and pain), compared to states without medical marijuana.
Source: WebMD Health - Category: Consumer Health News Source Type: news
(CNN) — People were curious about the keto diet, ALS and endometriosis in 2018. Those are just a few of the health-related topics that had Internet surfers in the United States turning to Dr. Google with questions this year, according to a top 10 list from the search engine giant. The data, based on search terms, was collected from January to mid-December. Last year, some of the top health-related questions searched on Google included what causes hiccups, how to stop snoring, how long flu lasts and what is lupus. Some of the top health-related questions on Google in 2016 were related to Zika, traumatic brain injuries...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat Google Local TV Source Type: news
CONCLUSION: Findings from a number of clinical and experimental paradigms suggest spinal cord OPCs/oligodendrocytes are a potential therapeutic target for the control of neuroinflammation. PMID: 29788868 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: May 2017 Source:PM&R, Volume 9, Issue 5, Supplement Author(s): Adam S. Tenforde, Jaye E. Hefner, Jodi E. Kodish-Wachs, Mary A. Iaccarino, Sabrina Paganoni Telehealth refers to health care interactions that leverage telecommunication devices to provide medical care outside the traditional face-to-face, in-person medical encounter. Technology advances and research have expanded use of telehealth in health care delivery. Physical medicine and rehabilitation providers may use telehealth to deliver care to populations with neurologic and musculoskeletal conditions, commonly treated in both acute care and ...
Source: PMandR - Category: Rehabilitation Source Type: research
The question is not whether disruptive technologies will transform the healthcare job market, but rather how and when will it happen. Healthcare navigators, augmented/virtual reality operation planners and nanomedicine engineers in the second part of my article series about future jobs in healthcare. As I am certain that the huge waves of technological change transform the medical professional palette; based on the current and prospective trends in digital health technologies I envisioned what potential new professions could appear in our lives. Don’t miss the first part of the list! If you have an idea about another...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine artificial intelligence augmented reality brain-computer interface cyborg gamification gc4 Health Innovation nanotechnology Personalized medicine psychology robotics virtual reality Source Type: blogs
Abstract The peripheral (PNS) and central nervous system (CNS) are delicate structures, highly sensitive to homeostatic changes-and crucial for basic vital functions. Thus, a selection of barriers ensures the protection of the nervous system from noxious blood-borne or surrounding stimuli. In this chapter, anatomy and functioning of the blood-nerve (BNB), the blood-brain (BBB), and the blood-spinal cord barriers (BSCB) are presented and the key tight junction (TJ) proteins described: claudin-1, claudin-3, claudin-5, claudin-11, claudin-12, claudin-19, occludin, Zona occludens-1 (ZO-1), and tricellulin are by now i...
Source: Pflugers Archiv : European Journal of Physiology - Category: Physiology Authors: Tags: Pflugers Arch Source Type: research
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