IgG4-related hypophysitis in patients with autoimmune pancreatitis

ConclusionsAlthough a large-scale study is necessary to validate these results, these data suggest that the prevalence of hypophysitis in patients with autoimmune pancreatitis may be underestimated. Based on our findings, we recommend screening for hypophysitis, especially in patients with multiple organ involvement.
Source: Pituitary - Category: Endocrinology Source Type: research

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Conclusion: Cholestasis resulting from primary duodenal papillary carcinoma is rare in pediatric patients but should be considered in the differential diagnosis.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In this report, we describe a case of IgG4-RD arising from bladder wall. This patient had a past history of autoimmune pancreatitis and presented with incidental bladder tumor. Magnetic resonance imaging showed low signal intensity tumor on T2-weighted image, and no invasion to the muscular layer. We performed transurethral resection. Pathological findings showed that there were chronic inflammatory changes infiltrates under the epithelium, and IgG4-positive plasma cells were scattered throughout the lesion. They met the pathological diagnostic criteria for IgG4-RD. We think this is the first case of IgG4-RD arising from a...
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
Advances in MR imaging with optimization of hardware, software, and techniques have allowed for an increased role of MR in the identification and characterization of pancreatic disorders. Diffusion-weighted imaging improves the detection and staging of pancreatic neoplasms and aides in the evaluation of acute, chronic and autoimmune pancreatitis. The use of secretin-enhanced MR cholangiography improves the detection of morphologic ductal anomalies, and assists in the characterization of pancreatic cystic lesions and evaluation of acute and chronic pancreatitis. Emerging MR techniques such as MR perfusion, T1 mapping/relaxo...
Source: Magnetic Resonance Imaging Clinics of North America - Category: Radiology Authors: Source Type: research
Autoimmune pancreatitis (AIP) is characterized by autoimmune inflammatory destruction of the pancreatic tissue. Imaging plays an essential role in the diagnosis. AIP type 1 is the pancreatic manifestation of immunoglobulin G4 (IgG4) –related disease and is associated with IgG4-positive plasma cell infiltration and fibrosis of multiple organ systems. Type 2 is a related disease with pancreatic inflammation with or without concurrent inflammatory bowel disease. The authors demonstrate the imaging findings that are associated wi th the pancreatic and extra-pancreatic manifestations of AIP. They emphasize the common MR i...
Source: Magnetic Resonance Imaging Clinics of North America - Category: Radiology Authors: Source Type: research
Conclusions:In cases of non-amnestic cognitive impairment with psychiatric manifestation, calcification on CT or MRI should be weighted more heavily as a sign of disease.It is plausible that the mother’s psychosis was actually caused by Fahr’s disease rather than schizophrenia. A positive family history of psychosis with presence of widespread calcification should put Fahr’s disease top on the differential.Disclosure: Dr. Fitzmorris has nothing to disclose. Dr. Bit-Ivan has nothing to disclose. Dr. Bit-Ivan has nothing to disclose. Dr. Bonakdarpour has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Behavioral and Cognitive Neurology: Cognitive Deficits in Neurological Disorders Source Type: research
CONCLUSION: The present study is the first to provide robust evidence that the presence of ansa pancreatica is significantly associated with recurrent acute pancreatitis. PMID: 27833385 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Authors: Yonenaga Y, Kushihata F, Watanabe J, Tohyama T, Inoue H, Sugita A, Takada Y Abstract Autoimmune pancreatitis (AIP) is a unique form of pancreatitis, histopathologically characterized by dense lymphoplasmacytic infiltration and fibrosis of the pancreas with obliterative phlebitis. AIP is associated with a good response to steroid therapy. Differentiation between AIP and pancreatic cancer to determine a preoperative diagnosis is often challenging, despite the use of various diagnostic modalities, including computed tomography (CT), magnetic resonance imaging and endoscopic retrograde cholangiopancreatography...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
PurposeTo evaluate the diagnostic value of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) parameters in differentiating patients with either a normal pancreas (NP), pancreatic ductal adenocarcinoma (PDAC), neuroendocrine tumor (NET), solid pseudopapillary tumor (SPT), acute pancreatitis (AcP), vs. autoimmune pancreatitis (AIP). Materials and MethodsIn all, 84 pathologically confirmed pancreatic tumors (60 PDACs, 15 NETs, 9 SPTs), 20 pancreatitis (13 AcPs, 7 AIPs), and 30 NP subjects underwent IVIM diffusion‐weighted imaging using 10 b‐values (0–900 sec/mm2) at 1.5T. The ADC, pure mol...
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research
PurposeTo evaluate the diagnostic value of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) parameters in differentiating patients with either a normal pancreas (NP), pancreatic ductal adenocarcinoma (PDAC), neuroendocrine tumor (NET), solid pseudopapillary tumor (SPT), acute pancreatitis (AcP), vs. autoimmune pancreatitis (AIP). Materials and MethodsIn all, 84 pathologically confirmed pancreatic tumors (60 PDACs, 15 NETs, 9 SPTs), 20 pancreatitis (13 AcPs, 7 AIPs), and 30 NP subjects underwent IVIM diffusion‐weighted imaging using 10 b‐values (0–900 sec/mm2) at 1.5T. The ADC, pure mol...
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research
We present a case of immunoglobulin G4 (IgG4)-related disease with pancreatic and extrapancreatic involvement, including the biliary and renal systems. Given the importance of imaging methods for the diagnosis of IgG4-related disease and its differentiation from pancreatic adenocarcinoma, we emphasize important abdominal computed tomography and magnetic resonance imaging findings related to this recently recognized systemic autoimmune disease.Resumo Apresentamos um caso de doença relacionada à IgG4, com acometimento pancreático e extrapancreático biliar e renal. Dada a relevância dos m&eac...
Source: Radiologia Brasileira - Category: Radiology Source Type: research
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