Comprehensive MicroRNAome Analysis of the Relationship Between Alzheimer Disease and Cancer in PSEN Double-Knockout Mice.

CONCLUSION: Based on literature reviews, many of the miRNAs involved in Cancer pathways were found to be known tumorsuppressive miRNAs, and their target genes were known or putative oncogenes. In conclusion, the expression levels of known tumor-suppressive miRNAs increased at 7 and 18 months, in the PSEN dKO mouse model of AD, supporting the negative correlation between AD and cancer. PMID: 30599494 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/30599494?dopt=Abstract

Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research