Lyme myelopathy: Case report and literature review of a rare but treatable disorder

We describe a rare case of a 56-year-old previously healthy male who presented with thoracic paresthesias and hyperesthesias involving the T6-11 dermatomes several weeks after a febrile illness. A thoracic MRI demonstrated a T7-10 transverse myelitis and an exhaustive evaluation revealed neuroborreliosis. His symptoms improved significantly after an initial steroid course and 21 day course of ceftriaxone. We review neuroborreliosis and summarize the features of 23 previously reported cases of Lyme myelopathy. Although Lyme myelopathy is rare, including Lyme in the differential diagnosis of an acute transverse myelitis work up is important in endemic regions, as it is a potentially reversible disorder with a generally good prognosis when appropriately treated with antibiotics.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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AbstractAnalysis of gut barrier status, monocyte and lymphocyte activation and T regulatory (Treg) cells at diagnosis before and after therapy, in patients with multiple sclerosis (MS). Analysis of differential effects of interferon beta (IFN- β), glatiramer acetate (GA) and natalizumab. Thirty-five patients with untreated MS were included. Gut barrier status (serum concentrations of intestinal fatty acid binding protein), monocyte (serum levels of soluble CD14, soluble CD163 and interleukin 6) and T lymphocyte activation (CD4 + DR+ and CD8 + DR+) and Treg (CD4 + CD25highFoxP3...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 January 2019Source: Neurología (English Edition)Author(s): M.L. Martínez-Ginés, J.M. García-Domínguez, M. Sarmiento, J. Maurino
Source: Neurologia - Category: Neurology Source Type: research
AbstractPurposeThe disease course of multiple sclerosis (MS) is unpredictable, and reliable prognostic biomarkers are needed. Positron emission tomography (PET) with β-amyloid tracers is a promising tool for evaluating white matter (WM) damage and repair. Our aim was to investigate amyloid uptake in damaged (DWM) and normal-appearing WM (NAWM) of MS patients, and to evaluate possible correlations between cerebrospinal fluid (CSF) β-amyloid1-42 (A β) levels, amyloid tracer uptake, and brain volumes.MethodsTwelve MS patients were recruited and divided according to their disease activity into active and non-act...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
CONCLUSIONS: Given the similarities in the in itial clinical profiles of these arboviruses, it is important to perform a detailed clinical analysis, laboratory diagnosis, and patient follow-up.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
TUESDAY, Jan. 15, 2019 -- For patients with relapsing-remitting multiple sclerosis (MS), nonmyeloablative hematopoietic stem cell transplantation (HCST) is associated with prolonged time to disease progression compared with disease-modifying therapy...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 14 January 2019Source: Veterinary MicrobiologyAuthor(s): Martina Besozzi, Stefania Lauzi, Davide Lelli, Antonio Lavazza, Chiara Chiapponi, Giuliano Pisoni, Roberto Viganò, Paolo Lanfranchi, Camilla LuzzagoAbstractMammalian orthoreoviruses (MRV) type 3 have been recently identified in human and several animal hosts, highlighting the apparent lack of species barriers. Here we report the identification and genetic characterization of MRVs strains in alpine chamois, one of the most abundant wild ungulate in the Alps. Serological survey was also performed by MRV neutralization test in c...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Condition:   Multiple Sclerosis Interventions:   Other: 'aerobic exercise';   Device: 'isokinetic exercise' Sponsor:   Okmeydani Training and Research Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Sclerosis Interventions:   Other: Classic, progressive endurance training;   Other: Periodized exercise training;   Dietary Supplement: beta-alanine Sponsor:   Hasselt University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Sclerosis Interventions:   Other: 'aerobic exercise';   Device: 'isokinetic exercise' Sponsor:   Okmeydani Training and Research Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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