Lyme myelopathy: Case report and literature review of a rare but treatable disorder

We describe a rare case of a 56-year-old previously healthy male who presented with thoracic paresthesias and hyperesthesias involving the T6-11 dermatomes several weeks after a febrile illness. A thoracic MRI demonstrated a T7-10 transverse myelitis and an exhaustive evaluation revealed neuroborreliosis. His symptoms improved significantly after an initial steroid course and 21 day course of ceftriaxone. We review neuroborreliosis and summarize the features of 23 previously reported cases of Lyme myelopathy. Although Lyme myelopathy is rare, including Lyme in the differential diagnosis of an acute transverse myelitis work up is important in endemic regions, as it is a potentially reversible disorder with a generally good prognosis when appropriately treated with antibiotics.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Authors: Ambrogi V, Murris M, Iriart X, Lortholary O, Roques C, Cassaing S, Malavaud S PMID: 32081504 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Publication date: Available online 22 February 2020Source: Journal of Theoretical BiologyAuthor(s): Salihu S. Musa, Shi Zhao, Daozhou Gao, Qianying Lin, Gerardo Chowell, Daihai HeAbstractLassa fever, also known as Lassa hemorrhagic fever, is a virus that has generated recurrent outbreaks in West Africa. We use mathematical modelling to study the Lassa fever epidemics in Nigeria from 2016-19. Our model describes the interaction between human and rodent populations with the consideration of quarantine, isolation and hospitalization processes. Our model supports the phenomenon of forward bifurcation where the stability betwee...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: May 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 189Author(s): Maroua Ben Haddada, Elise Gerometta, Rachid Chawech, Jonathan Sorres, Anne Bialecki, Sabrina Pesnel, Jolanda Spadavecchia, Anne-Laure MorelAbstractHubertia ambavilla, an endemic plant originating from Reunion Island in the Indian Ocean, is traditionally used as an anti-inflammatory and in healing, both for internal and external use. Polyphenolic compounds from aqueous phase extractions can reduce metal salts into nanoparticles and stabilize them in one step. Although gold nanoparticles are well described in the literature as anti...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: August 2020Source: Nonlinear Analysis: Real World Applications, Volume 54Author(s): Zhihui Ma, Shufan Wang, Xiaohua LiAbstractThe aim of this paper is to theoretically study the effect of the contacting distance (CTD) between the susceptible and infectious individuals in controlling infectious diseases. This paper formulates a generalized SEIR model incorporating the effect of the contacting distance (CTD). The dynamical behaviors of the proposed model are investigated and the controlling measures of the infectious diseases are developed. The results show that the contacting distance (CTD) between the sus...
Source: Nonlinear Analysis: Real World Applications - Category: Research Source Type: research
Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Chi Hou, Wenlin Wu, Yang Tian, Yani Zhang, Haixia Zhu, Yiru Zeng, Bingwei Peng, Kelu Zheng, Xiaojing Li, Wenxiong ChenAbstractObjective: To analyze the clinical features in children with anti-NMDAR encephalitis combined with myelin oligodendrocyte glycoprotein antibody (MOG ab).Methods: Clinical data of 7 children with anti-NMDAR encephalitis combined with MOG ab(+) were collected in Guangzhou Women and Children's Medical Center from January, 2016 to June, 2019. Children with NMDAR ab(+)/MOG ab(-) and MOG ab(+)/NMD...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionIn our study EDI symptoms could not be objectified since EDI and non-EDI groups did not differ in terms of change in mood, cognition and fatigue between day 0 and 7 suggesting that symptom recrudescence could be a subjective experience. Although our results need to be interpreted cautiously, we found no clear correlation between studied serum cytokines concentrations and the occurrence of EDI symptoms.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): J. Rigal, J. Ciron, Z. Lépine, D. BiottiAbstractFew cases of late onset neutropenia after RITUXIMAB treatment (LONART) have been reported in patients with neuroinflammatory disorders. We conducted a retrospective analysis of patients treated with RITUXIMAB for neuromyelitis optica spectrum disorders (NMOSD), MOG-antibody-associated disease (MOGAD) and multiple sclerosis (MS) at the Toulouse University Hospital from November 2007 to October 2019.Ten patients with LONART were identified in a total of 385 patie...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Alessio Amedoro, Anna Berardi, Antonella Conte, Elisa Pelosin, Donatella Valente, Giuseppe Maggi, Marco Tofani, Giovanni GaleotoAbstractBackgroundThe aquatic environment has unique properties, such a buoyancy, turbulence, hydrostatic pressure, and resistance, which can be used to gain a range of exercise benefits. During the last decade, hydrotherapy has spread in a very heterogeneous rehabilitation field. However, the efficacy of this kind of rehabilitation is not clear in scientific literature. The purpose of thi...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionTesting for MOG Abs should be considered in children with isolated and unexplained seizures, and in adults with suspected encephalitis and/or seizures. In these cases, MOG Abs detection is highly relevant for patients’ clinical management.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Mohammad Hossein Harirchian, Maryam Poursadeghfard, Alireza Sadeghipour, Hoda Kamali, Payam SarrafAbstractFingolimod has been the first approved oral medication in MS for its relapsing remitting type. It is a non-selective sphingosine1-phosphate (S1P) receptor modulator on lymphocytes. Engagement of this receptor blocks the T cells and B cells migration from the lymph nodes into the inflamed central nervous system (CNS) via bloodstream. In spite of this known immunomodulatory mechanism, there are some reports about...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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