Lyme myelopathy: Case report and literature review of a rare but treatable disorder

We describe a rare case of a 56-year-old previously healthy male who presented with thoracic paresthesias and hyperesthesias involving the T6-11 dermatomes several weeks after a febrile illness. A thoracic MRI demonstrated a T7-10 transverse myelitis and an exhaustive evaluation revealed neuroborreliosis. His symptoms improved significantly after an initial steroid course and 21 day course of ceftriaxone. We review neuroborreliosis and summarize the features of 23 previously reported cases of Lyme myelopathy. Although Lyme myelopathy is rare, including Lyme in the differential diagnosis of an acute transverse myelitis work up is important in endemic regions, as it is a potentially reversible disorder with a generally good prognosis when appropriately treated with antibiotics.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Publication date: May 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 5Author(s):
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
According to a 2013 study published in JAMA Psychiatry, one out of seven mothers suffers from postpartum depression (PPD). That’s 14 percent of all new moms. Katherine Stone, founder of Postpartum Progress, makes a good point that more women will suffer from postpartum depression and related illnesses this year than the combined number of new cases for men and women of tuberculosis, leukemia, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease and epilepsy. Even though, according to Dr. Ruta Nonacs of Massachusetts General Hospital and Harvard Medical School, PPD is the most common comp...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Mental Health and Wellness Parenting Pregnancy Self-Help Women's Issues Apathy Depressive Episode Postpartum Source Type: blogs
Publication date: Available online 19 April 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Faegheh Farhadi, Saba Soltani, Satar Saberi, Mehrdad IranshahiAbstractFerula ovina (Boiss.) Boiss is one of the most important endemic medicinal plants in Iran, which has three main terpenoid compounds including ferutinin, stylosin and tschimgine. Ferutinin is the strongest natural phytoestrogen that has agonistic activity on estrogen receptors, particularly α-receptors. To determine the amount of ferutinin in F. ovina roots, we firstly used HPLC-UV method. In the HPLC method, the resolution of ferutini...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: In our study, all patients with ON lost a significant amount of RGCL despite a full recovery of vision, as defined by our criteria. The percentage of RGCL loss varied from 5 - 27% and could not be correlated with any final visual indices. However, a correlation was found with the degree of initial visual loss. Despite sometimes marked RGCL loss after ON, patients with MS can recover normal visual function, according to standard clinical tests. PMID: 30999347 [PubMed - in process]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Authors: Sofizadeh A, Hanafi-Bojd AA, Shoraka HR Abstract Background &objectives: Zoonotic cutaneous leishmaniasis (ZCL) is among the most endemic zoonotic diseases in Golestan Province of Iran. The aim of this study was to find the high risk areas of this infection by considering the distribution of reservoirs and human infection. Methods: A cross-sectional study was conducted, in which Rhombomys opimus (Gerbils) were captured from different collection sites across the Golestan Province, Iran. records about the occurrence of Rh. opimus in the Province was obtained from earlier studies and were gathered in ...
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
Authors: Kadian K, Vijay S, Rawal R, Singh J, Anvikar A, Pande V, Sharma A Abstract Background &objectives: Plasmodium parasite harbours unique methylerythritol phosphate (MEP) pathway which is obligatory for the biosynthesis of isoprenoids. In malaria parasites, the isoprenoids are indispensable during hepatic, erythrocytic and gametocytic stages. Owing to the criticality of MEP pathway and the potential of its enzymes to act as antimalarial drug target, this study comprehensively investigated the genetic diversity and structural composition of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE), fourth en...
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
Authors: Fukushima K, Yanagisawa N, Kawabata H, Yajima K PMID: 30996189 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion: It is important to know about the prevalence of resistance and rising MIC values of commonly used antibiotics regarding Streptococcus pyogenes to avoid therapeutic failures. PMID: 30996826 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
Fogo Selvagem (FS) is a lethal skin disease mediated by pathogenic IgG4 autoantibodies to desmoglein-1 (Dsg1). FS is prevalent in certain regions of Brazil, where Leishmaniasis and Chagas disease are endemic. Normal individuals and leishmaniasis patients from these regions possess non-pathogenic anti-Dsg1 antibodies. They are chronically exposed to bites of the sand fly Lutzomyia longipalpis (LL), which elicits an IgG response to LL salivary proteins LJM17 and LJM11 and could contribute to the development of FS.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
The signaling lipid sphingosine 1-phosphate (S1P), which is abundant in lymph, guides T cell exit from lymph nodes (LN) into lymph by signaling through T cell S1P receptor 1 (S1PR1). By trapping pathogenic T cells within LN and preventing them from reaching their target tissues, drugs targeting S1PR1 have been successful in treating autoimmune diseases such as multiple sclerosis, and are being tested in dermatomyositis, psoriasis, graft versus host disease, and subacute cutaneous lupus erythematosus.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Neuro-Cutaneous Biology and Inflammation Source Type: research
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