Valeritas ’ V-Go wins preferred status on Humana’s Medicare formularies
Valeritas (NSDQ:VLRX) said today that its V-Go insulin delivery device won preferred status on Humana’s Part D formularies. The Bridgewater, N.J.-based company’s device is designed for people with Type 2 diabetes. Worn like a patch, the V-Go product delivers a continuous preset basal rate of insulin over 24 hours and can also provide on-demand bolus dosing at meals. Get the full story at our sister site, Drug Delivery Business News. The post Valeritas’ V-Go wins preferred status on Humana’s Medicare formularies appeared first on MassDevice.
We reported that, while autophagy was necessary for β cell survival, the highly conserved Sel1L-Hrd1 ERAD protein complex was required for the maintenance of β cell maturation and identity. Using single-cell RNA-Seq, we demonstrated that Sel1L deficiency was not associated with β cell loss, but rather loss of β cell identity. Sel1L-Hrd1 ERAD controlled β cell identity via TGF-β signaling, in part by mediating the degradation of TGF-β receptor 1. Inhibition of TGF-β signaling in Sel1L-deficient β cells augmented the expression of β cell maturation markers and increased the t...
Authors: Kobayashi M, Satoh H, Matsuo T, Kusunoki Y, Tokushima M, Watada H, Namba M, Kitamura T Abstract Glucagon dysfunction as well as insulin dysfunction is associated with the pathogenesis of type 2 diabetes (T2DM). However, it is still unclear whether the measurement of plasma glucagon levels is useful in understanding the pathophysiology of T2DM. We recently reported that sandwich ELISA provides more accurate plasma glucagon values than conventional RIA in healthy subjects. Here we used sandwich ELISA as well as RIA to assess plasma glucagon levels, comparing them in T2DM patients and healthy subjects during ...
CONCLUSION: Healing without major amputation was achieved in 84% of surviving patients ≥75 years, despite extensive comorbidity and dependency. PMID: 32448021 [PubMed - as supplied by publisher]
TYPE 2 diabetes can cause long term complications if blood sugar levels are not brought under control. Fortunately, making healthy lifestyle choices can ward off the threat of high blood sugar levels and taking a particular herbal extract has been shown to be effective.
CONCLUSION: The anti-inflammatory property is suggested the mechanism action of PG for protection human lymphocytes against genotoxicity induced by ionizing radiation. PMID: 32448107 [PubMed - as supplied by publisher]
Publication date: Available online 25 May 2020Source: Redox BiologyAuthor(s): Nadezda Apostolova, Francesca Iannantuoni, Aleksandra Gruevska, Jordi Muntane, Milagros Rocha, Victor M. Victor
In conclusion, mitochondrial fatty acid oxidation, and in particular MCAD, contributes to dicarboxylic acid degradation, but feeding dicarboxylic acids induces only the peroxisomal pathway. PMID: 32446361 [PubMed - in process]
Publication date: Available online 25 May 2020Source: American Journal of Kidney DiseasesAuthor(s): Christie Rampersad, Eyal Kraut, Reid H. Whitlock, Paul Komenda, Vincent Woo, Claudio Rigatto, Navdeep Tangri
INTRODUCTION: A sharp rise in the population of elderly people, who are more prone to somatic and mental diseases, combined with the high prevalence of type 2 diabetes mellitus and diabetes-associated complications in this age group, have an impact on the ...
TYPE 2 diabetes means the body doesn't use insulin properly - a hormone which regulates a person's blood sugar levels. Without proper treatment, toxic amounts of sugar can build up in the bloodstream, wreaking havoc from head to toe. Hypercoagulability often occurs due to this, but what is it?