New Acne Treatment Might Spring From Old One

THURSDAY, Jan. 3, 2019 -- An old acne drug may hold the key to developing a new, safer treatment, a study suggests. Isotretinoin (Myorisan, formerly branded as Accutane), is a form of vitamin A, and has been prescribed for acne for decades. It works...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

Related Links:

In this study, we investigated the safety, tolerability, and efficacy of VB-1953 topical gel in patients with moderate to severe acne having clindamycin-resistantC. acnes.MethodsAn investigator-initiated, open label, single-arm clinical study was conducted in patients with moderate to severe facial acne vulgaris showing poor or no response to previous clindamycin treatment. Nineteen subjects were enrolled in the study based on laboratory screening for the presence of clindamycin-resistantC. acnes in acne swab samples collected from patients. VB-1953 2% gel was applied on the entire face twice daily over 12  weeks. The...
Source: Drugs in R&D - Category: Drugs & Pharmacology Source Type: research
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa.
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
We present herein a 20-year-old woman with multiple vulvar condylomata acuminata who developed EN two weeks after onset of oral isotretinoin therapy. To the best of our knowledge, this is the first report of EN occurring during isotretinoin treatment in a patient without acne and strongly indicates that the pathogenesis of EN can be directly related to the biological actions of isotretinoin. Erythema nodosum should be regarded as a rare...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
We present a 26-year-old man with a history of pemphigus foliaceus (PF) who developed large draining nodules with scarring and sinus tracts, compatible with follicular occlusion triad, preferentially at areas previously affected by PF thirteen months after treatment with rituximab. To the authors' knowledge there are no reported cases of follicular occlusion triad or HS manifesting as an isotopic response. However, one member of the triad, HS, has been reported to occur infrequently following the use of biologic agents...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
Condition:   Acne Vulgaris Interventions:   Drug: Clindamycin Phosphate;   Drug: Clindamycin Phosphate RLD;   Drug: Placebos Sponsor:   Taro Pharmaceuticals USA Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
New treatments and tips are available for this “complex inflammatory disorder of the skin.”
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
P. TANNGOEN, S. LAMLERTTHON, AND W. TIYABOONCHAI,
Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
In the midst of this coronavirus pandemic, a friend of mine relayed a troubling story to me recently. My friend is a dermatologist who is 9-months pregnant, living and working in a county with no known community spread of the novel coronavirus.  After spending time examining a 19-year-old with acne, the patient told her that she […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs
“Autoinflammatory disease (AiD)” has first been introduced in 1999 when the responsible gene for the familial Hibernean fever or autosomal dominant-type familial Mediterranean fever-like periodic fever syndrome was reportedly identified as tumor necrosis factor receptor superfamily 1. Linked with the rapid research progress in the field of innate immunity, “autoinflammation” has been designated for dysregulated innate immunity in contrast to “autoimmunity” with dysregulated acquired immunity. As hereditary periodic fever syndromes represent the prototype of AiD, monogenic systemic diseas...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This case series demonstrates how the use of photodynamic therapy, specifically via light-emitting diodes, can provide an effective, safe, and well-tolerated alternative treatment for acne rosacea.Journal of Medical Case Reports
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
More News: Absorica | Accutane | Acne | General Medicine | Study | Vitamin A | Vitamins