GABAA receptor signalling mechanisms revealed by structural pharmacology

GABAA receptor signalling mechanisms revealed by structural pharmacologyGABA<sub>A</sub> receptor signalling mechanisms revealed by structural pharmacology, Published online: 02 January 2019; doi:10.1038/s41586-018-0832-5Cryo-electron microscopy structures are reported in which the full-length human α1β3γ2L GABAA receptor in lipid nanodiscs is bound to the channel-blocker picrotoxin, the competitive antagonist bicuculline, the agonist GABA, and the benzodiazepines alprazolam and diazepam.

https://www.nature.com/articles/s41586-018-0832-5

Source: Nature AOP - January 2, 2019 Category: Research Authors: Simonas Masiulis Rooma Desai Tomasz Ucha ński Itziar Serna Martin Duncan Laverty Dimple Karia Tomas Malinauskas Jasenko Zivanov Els Pardon Abhay Kotecha Jan Steyaert Keith W. Miller A. Radu Aricescu Source Type: research