Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model

AbstractWhile the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure model. High esmolol dose, targeting a 50% reduction in CO from healthy baseline, resulted in a failure state with mean CO 1.9  L/min. Heart assist with the device during failure state resulted in an average absolute increase in CO of 1.0 L/min, along with a decline in ventricular work to 67.5% of the total LV SW. Combined with repeated success of minimally invasive device implant, the resulting increases in cardiac hemod ynamics achieved while still unloading the heart demonstrate the potential of the CorInnova device for temporary heart assist.
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research