A three-gene methylation marker panel for the nodal metastatic risk assessment of muscle-invasive bladder cancer

ConclusionsWe identified a methylation marker panel suitable to differentiate between patients with positive and negative lymph nodes at time of cystectomy. This enables a risk assessment for patients who potentially benefit from extended lymph node resection as well as from neoadjuvant chemotherapy and could improve the survival rates. Furthermore, we examined the impact of putative markers on tumor behavior. Hence, KISS1R and SEPT9 could represent a starting point for the development of novel therapy approaches.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research