Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.

CONCLUSION: Our results characterize TBX2 as a repressor of ADAM10 gene expression and suggest that this regulatory interaction is conserved across tissues and species.
PMID: 30599067 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - January 1, 2019 Category: Cytology Authors: Reinhardt S, Schuck F, Stoye N, Hartmann T, Grimm MOW, Pflugfelder G, Endres K Tags: Cell Mol Life Sci Source Type: research