Association of human leukocyte antigens ‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population
ConclusionThese results suggested that the functional HLA ‐DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well ‐designed studies are expected to confirm these preliminary findings.
In conclusion, it seems essential to implement effective educational and informative activities targeted to parents to reinforce positive attitudes toward vaccinations. PMID: 31705322 [PubMed - as supplied by publisher]
Two large public image datasets commonly used to train artificial intelligence...Read more on AuntMinnie.comRelated Reading: AI needs robust clinical evaluation in healthcare AI may help improve sensitivity of ED chest x-ray reads AI model could speed up pneumonia diagnosis in ED Are studies on AI for tuberculosis really valid? AI tops recent imaging informatics highlights
[The Conversation Africa] Important gains have been made in the global fight against tuberculosis (TB). Each year, fewer people are being diagnosed with the disease. The recent World Health Organisation (WHO) global TB report, which gathers data from 202 countries and territories, shows a 6.3% reduction in the number of new TB infections between 2015 and 2018. This trend of decreasing incidence is also evident in Africa, where it fell from 275 per 100 000 people in 2015 to 231 per 100 000 in 2018.
Conclusions: The spatial clusters of TB incidence shifted to the rural region and the fringe of the new urban area of Nanchang. Targeted management strategies for urban migrants in the process of urbanization should be strengthened.
BCG stimulation promotes dendritic cell proliferation and expression of VDR and CYP27B1 in vitamin D‑deficient mice. Mol Med Rep. 2019 Oct 30;: Authors: Yang H, Zhang H, Li Y, Xiang L, Liu J Abstract Vitamin D deficiency may lead to an increased risk of tuberculosis. In the present study, the effects of Mycobacterium tuberculosis (Mtb) infection on dendritic cells (DCs) derived from vitamin D‑deficient mice or normal control mice were investigated. A vitamin D‑deficient mouse model was established, and bone marrow‑derived DCs (BMDCs) were isolated and treated with GM‑CSF and in...
ConclusionsThis study shows that the alveolar microbiota profile in BAL samples from TB and IP patients, representing infectious and non-infectious lung diseases, respectively, is characterized by decreased diversity.
Publication date: Available online 8 November 2019Source: Respiratory InvestigationAuthor(s): Lucia Vietri, Annalisa Fui, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, Piersante Sestini, Paola Rottoli, Elena BargagliAbstractSerum amyloid A is an acute-phase protein with multiple immunological functions. Serum amyloid A is involved in lipid metabolism, inflammatory reactions, granuloma formation, and cancerogenesis. Additionally, serum amyloid A is involved in the pathogenesis of different autoimmune lung diseases. The levels of serum amyloid A has been evaluated in biological fluids of patients with different...
Publication date: Available online 9 November 2019Source: Respiratory Medicine Case ReportsAuthor(s): Wajahat Dawood, De La Garza Henriette, Gloria Iliescu, Cesar Moran, Horiana Grosu