Kiwifruit seed oil prevents obesity by regulating inflammation, thermogenesis, and gut microbiota in high-fat diet-induced obese C57BL/6 mice.

Kiwifruit seed oil prevents obesity by regulating inflammation, thermogenesis, and gut microbiota in high-fat diet-induced obese C57BL/6 mice. Food Chem Toxicol. 2018 Dec 28;: Authors: Qu L, Liu Q, Zhang Q, Tuo X, Fan D, Deng J, Yang H Abstract Obesity is considered as a chronic disease which seriously affecting people's health and daily life. Kiwifruit (Actinidia chinensis Planch) seed oil (KSO), as a by-product of kiwifruit processing, is rich in fatty acids. Conventional wisdom holds that KSO has many health benefits, but there is no scientific basis. Here, the relieving effects of KSO on obesity and its potential mechanism were investigated in high-fat diet (HFD)-induced C57BL/6 mice. Mice were divided into four groups: ND (normal diet); HFD; L-KSO and H-KSO (HFD supplemented with 1.0 and 3.0 mL/kg·bw of KSO per day, respectively). Results showed that continuous supplementation KSO for 12 weeks significantly decreased bodyweight, inguinal fat tissue weight, blood glucose, and HOMA-IR index and ameliorated serum lipids accumulation (TC, TG, HDL-C, and LDL-C). Relative mRNA expression of inflammatory cytokines (TNF-α, IL-6, IL-1β, COX-2, and iNOS) was down-regulated and expression of thermogenesis-related genes (PPAR-γ, UCP1, PGC1-α, and PRDM16) was up-regulated in the inguinal fat tissue of KSO treated mice. Principal component analysis showed that the microbial community compositions of four groups were different. KSO supp...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research