Use of the Spiritual Development Framework in Conducting Spirituality and Health Research with Adolescents

AbstractSpirituality is considered a universal phenomenon, but research addressing the spiritual needs of adolescents in the context of health and illness is limited. The aim of this article is to provide a description of how the spiritual development framework (SDF) was used in conducting research with adolescents. An exemplar of a qualitative descriptive study is provided to demonstrate applicability of the SDF. The SDF was used as a guiding theoretical framework in conducting research with adolescents living with sickle cell disease. The SDF is culturally applicable and methodologically appropriate. Additional research applying the SDF is warranted.
Source: Journal of Religion and Health - Category: Medical Ethics Source Type: research

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A team of Brown University researchers has developed a new computer model that simulates the way red blood cells become misshapen by sickle cell disease. The model, described in a paper published in Science Advances, could be useful in the preclinical evaluation of drugs aimed at preventing the sickling process.
Source: eHealth News EU - Category: Information Technology Tags: Featured Research Research and Development Source Type: news
An unmet need for therapies exists to reduce sickle cell disease (SCD) complications in pediatric patients. Activated platelets contribute to the formation of cellular aggregates during sickling and vaso-occlusive crises (VOCs). Ticagrelor is an oral, direct-acting, and reversible adenosine diphosphate P2Y12 receptor antagonist that inhibits platelet activation and aggregation. Although ticagrelor was well tolerated in two phase 2 studies in children and young adults with SCD, larger and longer-term treatment studies are needed to assess ticagrelor's efficacy to reduce VOCs.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Source Type: research
Urticarial vasculitis is a rare diagnosis defined by its distinct clinical and pathologic entities. The majority of cases are idiopathic; however, it has been linked to various etiologies including autoimmune, viral, paraneoplastic as well as pharmacotherapy. A 42-year-old Jamaican woman G1PO with sickle cell trait was admitted for persistent fevers and rigors for 2 weeks. This was associated with progressive burning, erythematous, raised plaques and patches involving the chest and trunk. While hospitalized she continued to spike fevers up to 103 °F despite being on broad spectrum antibiotics and acetaminophen.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Sickle cell disease (SCD) is a medical condition in which chronic pain is common and negatively impacts psychosocial function and quality of life. Although the brain mechanisms underlying chronic pain are well studied in other painful conditions, the brain mechanisms underlying chronic pain and the associated psychosocial comorbidities are not well established in SCD. A growing literature demonstrates the effect of treatment of chronic pain, including pharmacological and nonpharmacological treatments, on brain function. The present systematic review aimed to (1) determine the effects of chronic pain and psychosocial comorb...
Source: Pain - Category: Anesthesiology Tags: Systematic Reviews and Meta-Analyses Source Type: research
Condition:   Heart Rate Variability (ANS Function) Intervention:   Sponsor:   Assistance Publique - Hôpitaux de Paris Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Prevention and proper management of Sickle cell disease and malaria reduces paediatric hospital stay in our environment. Paediatric  emergency medicine should be re-organized to cater for high volume of off-hour admissions.Keywords: Paediatric emergency, paediatric emergency admissions, predictors of prolonged stay, children emergency unit.
Source: African Health Sciences - Category: African Health Source Type: research
Abstract Hydroxyurea (HU) has been widely used in sickle cell disease. Its potential long-term risk for carcinogenesis or leukemogenic risk remains undefined. Here, we report a 26 y old African-American female with Sickle Cell Disease (SCD) who developed refractory/relapsed acute myeloid leukemia (AML) 6 months after 26 months of HU use. That patient's cytogenetics and molecular genetics analyses demonstrated a complex mutation profile with 5q deletion, trisomy 8, and P53 deletion (deletion of 17p13.1). P53 gene sequence studies revealed a multitude of somatic mutations that most suggest a treatment-related etiolo...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
Conclusions: Rarely, an emergency splenectomy is required in complex settings, mostly refractory hematological conditions, in a deteriorating patient when all other measurements have failed. A multidisciplinary team approach is mandatory in the treatment of these complex cases.What is known• Conservative treatment is advised for splenic injury.• Many hematological disorders are responsible of splenic pathology.What is new• Emergency splenectomy in children for reasons other than trauma is a treatment of last resort that should be performed in a multidisciplinary context.• The outcome of emergency splene...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Conditions:   Chronic Cutaneous Ulcer;   Sickle Cell Disease Interventions:   Drug: Deferoxamine Product;   Other: Placebo Sponsor:   TauTona Group Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions The proposed strategy of submaximal incremental exercise allowed safe determination of LT1, an important parameter of patients’ physical ability. The study also demonstrated the feasibility and safety of individually tailored endurance exercises at ~2.5 mmol·L−1 of [lactate]b. These latter results suggest that endurance training programs may be considered for adult SCD patients and that the method proposed here may be helpful in that regard.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
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