ER-stress regulates macrophage polarization through pancreatic EIF-2alpha kinase.

In this study, we found that the PA mediated ER-stress activation could induce M1-type polarization in macrophages, and this phenotype polarization could be inhibited by ER-stress inhibitor 4-PBA as well as GSK2656157, an inhibitor of PERK. Moreover, the knockdown of PERK altered the STAT1 and STAT6 pathways in macrophages, which then led to the M1-to-M2 phenotypic shift. In summary, we found that PERK could regulate the phenotypic polarization of macrophages. This finding may provide new insight into the suppression of pathological progression of fatty liver or liver ischemia reperfusion injury induced by M1-type macrophages. PMID: 30594305 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30594305?dopt=Abstract

Source: Cellular Immunology - December 21, 2018 Category: Allergy & Immunology Authors: Yang F, Liu Y, Ren H, Zhou G, Yuan X, Shi X Tags: Cell Immunol Source Type: research