Soluble ST2 and CD163 as Potential Biomarkers to Differentiate Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome

Conclusion: Patients with pHLH and MAS show some differences in cytokine profiles. The elevated levels of IFN- γ, IL-10, IL-18 and TNF-α can contribute to the diagnosis of HLH, but may not discriminate pHLH from MAS. Levels of sST2 and sCD163 may serve as markers to distinguish pHLH from MAS.
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research