Cytoplasmic M ‑CSF facilitates apoptosis resistance by inhibiting the HIF‑1α/BNIP3/Bax signalling pathway in MCF‑7 cells.

In conclusion, cytoplasmic M‑CSF suppressed apoptosis by inhibiting the HIF‑1α/BNIP3/Bax signalling pathway, which potentiated the dissociation of Bcl‑2 from Bcl‑2‑BNIP3 compounds and the formation of Bcl‑2‑Bax compounds. PMID: 30592292 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research