Delivery of Liposome Encapsulated Temozolomide to Brain Tumour: understanding the drug transport for optimisation

In this study, mathematical modelling is applied to simulate the liposome-mediated delivery of temozolomide under different conditions in a 3-D realistic brain tumour model reconstructed from MR images. Delivery outcomes are evaluated by the bioavailability of free temozolomide across time. As compared to the oral and intravenous administration of free temozolomide, liposome-mediated delivery can successfully improve the drug accumulation in tumour while reducing the drug exposure in blood and normal tissue. Results show that the delivery is less sensitive to the duration of intravenous infusion but highly dependent on the liposome properties. The treatment can be improved by either enhancing the liposome transvascular permeability or using the liposomes with high extracellular release rates. Intravascular release can only increase the risk of adverse effects rather than improving the drug bioavailability in tumour. Results obtained in this study could be applied for optimising the treatment using liposome encapsulated temozolomide.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research