Role of mesenchymal stromal cell-derived extracellular vesicles in tumour microenvironment

Publication date: Available online 30 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): A. Adamo, G. Dal Collo, R. Bazzoni, M. KramperaAbstractStromal cells, deriving from mesenchymal stromal cells (MSCs), are crucial component of tumour microenvironment and represent key regulators of tumour processes. MSCs can be recruited to the tumour environment and interact with many cellular elements, thus influencing tumour biology. Cell-to-cell communication is in part mediated by the release of extracellular vesicle (EVs). EVs can induce significant molecular changes in recipient cells, delivering bioactive molecules. In this review, we describe the MSC-derived EVs content and discuss their role in different processes related to cancer biology. Furthermore, we summarize chemical or biological EVs modifications aiming to develop more efficient antitumor therapies.
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research