Hierarchical Network Meta-Analysis Incorporating Ordering Constraints on Increasing Doses of Interventions - Application to Overactive Bladder Syndrome

For the conservative treatment of Overactive Bladder (OAB) symptoms, the National Institute for Health and Care Excellence (NICE) in the UK currently recommends a course of supervised pelvic floor muscle training, behavioural therapy, anticholinergic medication, sacral nerve stimulation, and more recently, botulinum toxin type A (BoNTA) and Mirabegron. Given the large number of interventions and relatively few primary trials, network meta-analyses (NMAs) produce considerable uncertainty in the estimated treatment effects and consequently, there is little evidence of the most clinically effective intervention.
Source: Value in Health - Category: Global & Universal Authors: Source Type: research