Mediation Formulas with Binary Mediators and Outcomes and the "Rare Outcome Assumption".

Mediation Formulas with Binary Mediators and Outcomes and the "Rare Outcome Assumption". Am J Epidemiol. 2018 Dec 24;: Authors: VanderWeele TJ, Valeri L, Ananth CV Abstract Samoilenko and Lefebvre correctly note two typos in the formulas in the 2011 paper of Ananth and VanderWeele on placental abruption. Fortunately, to the best of our knowledge, researchers are using our methods papers, and our book on mediation analysis, rather than our paper on placental abruption, to carry out their direct and indirect effect analyses; and in our methods papers, and the book, the formulas are correct. The formulas discussed by Samoilenko and Lefebvre, and in our work, make reference to a "rare outcome assumption." In evaluating this assumption, it is important to note that the outcome is to be relatively rare across all strata defined by the exposure and the mediator, a point which is often neglected. PMID: 30590417 [PubMed - as supplied by publisher]
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
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