The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care

The authors of this journal article state that sepsis is the third leading cause of death worldwide and the main cause of mortality in hospitals, but the best treatment strategy remains uncertain. In particular, evidence suggests that current practices in the administration of intravenous fluids and vasopressors are suboptimal and likely induce harm in a proportion of patients. To tackle this sequential decision-making problem, the authors developed a reinforcement learning agent, the Artificial Intelligence (AI) Clinician, which extracted implicit knowledge from an amount of patient data that exceeds by many-fold the life-time experience of human clinicians and learned optimal treatment by analyzing a myriad of (mostly suboptimal) treatment decisions. They demonstrate that the value of the AI Clinician's selected treatment is on average reliably higher than human clinicians. In a large validation cohort independent of the training data, mortality was lowest in patients for whom clinicians'actual doses matched the AI decisions. The model provides individualized and clinically interpretable treatment decisions for sepsis that could improve patient outcomes.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Authors: Handra-Luca A PMID: 31416300 [PubMed - as supplied by publisher]
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
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Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01275C, CommunicationSengodagounder Muthusamy, Ammasi Prabu, E Suresh An atom-economical synthesis of spiro-indolofurobenzopyrans has been developed from diazoamides and O-propargyl salicylaldehydes in the presence of copper(I) thiophene-2-carboxylate in a diastereoselective manner. This methodology involves the carbonyl ylide intermediates... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Conclusion Dexamethasone appears to be a promising agent in reduction of post-operative sequelae in third molar surgery. As a potent anti-inflammatory agent it has an effective role in pain, trismus and edema reduction distinguish from the routes of administration, dosage and timing, pre or post-operative prescription. PMID: 31416411 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Methods to Quantify the NF-κB Pathway During Senescence. Methods Mol Biol. 2019;1896:231-250 Authors: Zhang L, Zhao J, Gurkar A, Niedernhofer LJ, Robbins PD Abstract Nuclear factor κB (NF-κB) is a family of transcription factors important for regulating innate and adaptive immunity, cellular proliferation, apoptosis and senescence. The NF-κB family is comprised of five subunits, RelA/p65, RelB, C-Rel, p50 (p105/NF-κB1), and p52 (p100/NF-κB2). NF-κB activity goes up with age in multiple tissues. The two subunits RelA/p65 and p50 have been implicated in senescen...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
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Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
In this study, site-specific release retardant mini-matrix tablets (SSRRMT) were developed and functionally coated with pH-responsive materials to achieve a site-specific delivery of DT at the duodenojejunal (DSRRMT) and ileocecal (ISRRMT) regions. Stomach-specific coated mini-tablets (SSCMT) were manufactured for immediate release of about 16% of the daily dose of DT in the stomach. The SSCMT, DSRRMT and ISRRMT were combined into a solid dosage form (C-SSRRMT tablets or capsules) to achieve the required linear release profile for once daily administration of DT. The SSRRMT and C-SSRRMT formulations were evaluated for the ...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
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Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
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Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
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