Cancer Risk Following Bariatric Surgery —Systematic Review and Meta-analysis of National Population-Based Cohort Studies

This study has analyzed results from registry-based population studies to assess the effect of bariatric surgery upon cancer incidence at a population level. Relevant studies were identified and meta-analysis was used to calculate pooled odds ratios (POR) for the incidence of cancer after bariatric surgery compared to controls. Eight population-based studies were included with 635,642 total patients. Bariatric surgery was associated with a significant reduction in overall cancer incidence (POR  = 0.72; 95% CI 0.59 to 0.87;p = 0.0007) and incidence of obesity-related cancer (POR = 0.55; 95% CI 0.31 to 0.96;p = 0.04). Bariatric surgery was also protective for breast cancer development (POR = 0.50; 95% CI 0.25 to 0.99;p = 0.045). Bariatric surgery appears to be associated with a reduction in cancer incidence at a population-based level.
Source: Obesity Surgery - Category: Surgery Source Type: research