Genetic testing for kidney disease may become routine, researchers say

About 10 percent of all cases of chronic kidney disease come from genetic causes, a new study says.
Source: Health News - - Category: Consumer Health News Source Type: news

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Authors: Hildegard Stancu S, Stanciu A, Lipan M, Capusa C Abstract Rationale: Anemia, a common feature in chronic kidney disease (CKD), has multiple contributors to its pathogenesis. Besides the well recognized erythropoietin and iron deficiencies, hydration status might be involved. Objective: To assess the prevalence and correlations of anemia, iron deficiency and overhydration in patients with stage 2 to 5 CKD. Methods and Results: This cross-sectional study enrolled 125 erythropoietin and iron therapy naïve non-dialysis CKD patients, without a identifiable cause of anemia. Parameters of hematological, iron...
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
Publication date: April 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 4Author(s): Holly J. Kramer, Raymond R. Townsend, Karen Griffin, Joseph T. Flynn, Daniel E. Weiner, Michael V. Rocco, Michael J. Choi, Matthew R. Weir, Tara I. Chang, Rajiv Agarwal, Srinivasan BeddhuHypertension is a modifiable risk factor for cardiovascular morbidity and mortality and reduction of elevated blood pressure (BP) remains an important intervention for slowing kidney disease progression. Over the past decade, the most appropriate BP target for initiation and titration of BP-lowering medications has been an area of intense ...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Publication date: April 2019Source: Archives of Cardiovascular Diseases Supplements, Volume 11, Issue 2Author(s): A. Méloux, L. Rochette, M. Maza, F. Bichat, J.C. Beer, F. Chagué, Y. Cottin, M. Zeller, C. Vergely-VandriesseBackgroundGrowth differentiation factor 15 (GDF15) is an emerging biomarker in cardiovascular (CV) diseases. GDF15 is weakly expressed in normal condition but increased in pathological situations such as inflammation, oxidative stress, and left ventricular remodeling. Recent data suggest GDF15 as a marker in heart failure (HF).PurposeWe aimed to identify the determinants of GDF15 circulatin...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
CONCLUSION: In Portugal, the level of prescribing of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus should be reduced, particularly in the subgroups identified with higher prescription and with higher risk of progression to stage 5 chronic kidney disease. PMID: 30896392 [PubMed - in process]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminuria susceptibility locus detected in these models. We characterized its genomic architecture by congenic substitution mapping, targeted next generation sequencing, and compartment-specific RNA sequencing analysis in isolated glomeruli. This led to prioritization of transmembrane proteinTmem63cas a novel potential target.Tmem63c is differentially expressed in glomeruli of allele-...
Source: eLife - Category: Biomedical Science Tags: Genetics and Genomics Source Type: research
ConclusionsSpecialist and PCP visit in the immediate post-discharge period may improve 90-day HF readmission and mortality in certain high-risk groups of patients with HF.
Source: American Heart Journal - Category: Cardiology Source Type: research
Authors: Li Q, Zhang A, Xing C, Yuan Y Abstract Chronic kidney disease (CKD) is recognized as a worldwide health problem. Progression of CKD may lead to many serious complications, which are associated with increased morbidity and mortality. Presently, there is no satisfactory treatment. Thus, targeted therapies are urgently needed. The kidneys are second to the heart in terms of mitochondrial abundance and oxygen consumption. Thus, it is not surprising that mitochondrial homeostasis is absolutely essential for the normal function of the kidney. In fact, a number of reports indicate that mitochondria are involved i...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Conclusion: Among adolescents in a nationally representative survey, hypernatremia and hyperosmolality were associated with high SBP and decreased eGFR. These findings may support the hypothesis that an imbalance of salt and water contribute to hypertension and CKD.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
Publication date: Available online 19 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Junichi Ishigami, William V. Padula, Morgan E. Grams, Alexander R. Chang, Bernard Jaar, Ron T. Gansevoort, John F.P. Bridges, Csaba P. Kovesdy, Shinichi Uchida, Josef Coresh, Kunihiro MatsushitaRationale &ObjectivePneumococcal vaccine is recommended for adults 65 years and older and those younger than 65 years with clinical indications (eg, diabetes, lung/heart disease, kidney failure, and nephrotic syndrome). Its cost-effectiveness in less severe chronic kidney disease (CKD) is uncharacterized.Study DesignCost-effecti...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Publication date: Available online 19 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Elaine Ku, Benjamin J. Lee, Jenny Wei, Matthew R. WeirHypertension and chronic kidney disease (CKD) are closely interlinked pathophysiologic states, such that sustained hypertension can lead to worsening kidney function and progressive decline in kidney function can conversely lead to worsening blood pressure (BP) control. The pathophysiology of hypertension in CKD is complex and is a sequela of multiple factors, including reduced nephron mass, increased sodium retention and extracellular volume expansion, sympathetic nerv...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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