For patients with kidney disease, genetic testing may soon be routine

(Columbia University Irving Medical Center) DNA sequencing can be used to identify the underlying genetic cause of many rare types of chronic kidney disease, leading to better treatment, finds a new study from Columbia University.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionsHPR conversions occur in a significant proportion of CKD patients with maintenance doses of clopidogrel treatment post-PCI, and this conversion was not confined to CYP2C19 loss-of-function genotype carriers. Risk stratification for treatment adjustment in personalized antiplatelet therapy should be investigated in future research.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Li C, Yap DYH, Chan G, Wen YB, Li H, Tang C, Li XM, Li XW, Chan TM Abstract OBJECTIVE: Renal thrombotic microangiopathy (TMA) is an uncommon pathological finding in lupus nephritis (LN), and its clinical significance remains to be defined. METHODS: 24 patients with lupus nephritis (LN) and renal TMA were selected from a retrospective review of 677 biopsy-proven LN patients, and compared with 48 LN Controls without TMA (in 1:2 ratio) matched according to demographics and treatments. RESULTS: Renal TMA was noted in 3.5% of kidney biopsies of LN. TMA was associated with a higher prevalence of anti-Ro ...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
An estimated 14.8% of adults have chronic kidney disease (CKD).1 Diabetic kidney disease (DKD) is classified according to the presence of microalbuminuria or macroalbuminuria.2 Of the 30 million US individuals with diabetes, those who met any criteria for DKD is estimated at 26.2%. Using 2010 census data, this translates to a prevalence of approximately 8.2 million people with any DKD, including 4.6 million people with albuminuria, 1.9 million people with macroalbuminuria, 4.5 million people with reduced estimated glomerular filtration rate (eGFR), and 0.9 million people with severely reduced eGFR.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Patient Education Source Type: research
Advanced kidney disease is often considered a relative contraindication to LVAD implantation and many implanting centers view stage 4 and 5 chronic kidney disease (CKD) as an absolute contraindication. We sought to analyze the impact of CKD at the time of LVAD implant on outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 572 Source Type: research
Acute Kidney Injury (AKI) is known to be associated with poor outcomes in patients undergoing Left ventricular assist device (LVAD) implantation. We sought to determine the trends and predictors of AKI in this patient population.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 571 Source Type: research
A retrospective multi-center cohort study was conducted, including all patients undergoing LVAD implantation. The Chronic Kidney Disease Epidemiology collaboration equation was used to determine the estimated glomerular filtration rate. Creatinine measurements were collected over a 2-year follow-up period. Patients stratification was based on their pre-operative CKD stage.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 563 Source Type: research
This study was conducted to determine the rate of AKI and CKD post LT and recovery of AKI while using IVFK.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 760 Source Type: research
Inpatient management of patients with heart failure (HF) and chronic kidney disease (CKD) is challenging. We studied the role of hand carried ultrasound (US) in directing clinical care.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 958 Source Type: research
Authors: International Journal Of Nephrology Abstract [This retracts the article DOI: 10.1155/2018/2903139.]. PMID: 30867964 [PubMed - in process]
Source: International Journal of Nephrology - Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research
To evaluate the characteristics of type 2 diabetes (T2DM) patients with or without chronic kidney disease (CKD) in Germany.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
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