Plasma Cells are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease

Development of celiac disease is believed to involve the transglutaminase-dependent response of CD4+ T cells toward deamidated gluten peptides in the intestinal mucosa of individuals with specific HLA-DQ haplotypes. We investigated the antigen presentation process during this mucosal immune response.

Source: Gastroenterology - December 26, 2018 Category: Gastroenterology Authors: Lene St økken Høydahl, Lisa Richter, Rahel Frick, Omri Snir, Kristin Støen Gunnarsen, Ole JB. Landsverk, Rasmus Iversen, Jeliazko R. Jeliazkov, Jeffrey J. Gray, Elin Bergseng, Stian Foss, Shuo-Wang Qiao, Knut EA. Lundin, Jørgen Jahnsen, Frode L. Jahns Source Type: research