12: Evidence for the crucial role of estrogen signaling with preterm labor and perinatal neuroinflammation

Female offspring are less susceptible to prematurity-related neuroinflammatory injury than males. We hypothesize such differences are attributed to sex-specific hormones, specifically estrogen. Using a murine prematurity model, we evaluated the role of estrogen signaling in the process of perinatal brain injury following exposure to intrauterine inflammation (IUI) by: 1) Characterizing the principle components of signaling (Esr1 and Esr2) and synthesis (Cyp19) and 2) Evaluating the phenotype with Esr1 deletion.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Oral Concurrent 1 Source Type: research