842: Role of inflammation in uterine isthmus leading to uterine atony: pathophysiology of Amniotic Fluid Embolism.

Amniotic Fluid Embolism (AFE) is one of the leading causes of maternal deaths in Japan. Our Investigations have revealed Postpartum Acute Myometritis (PAM) with massive infiltration of inflammatory cells into the uterine myometrium affected by AFE, which can induce contractile dysfunction. We focus now on uterine isthmus which lies just adjacent to uterine body. Uterine isthmus undergoes marked structural change throughout normal pregnancy and becomes elongated significantly. It is composed of a mixture of myocytes from body and fibroblasts with extracellular matrix which forms the passive lower uterine segment during labor in vaginal delivery.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session IV Source Type: research