Nucleus-Invadopodia Duo During Cancer Invasion.

Nucleus-Invadopodia Duo During Cancer Invasion.
Trends Cell Biol. 2018 Dec 17;:
Authors: Ferrari R, Infante E, Chavrier P
Abstract
Matrix proteolysis mediated by MT1-MMP facilitates the invasive migration of tumor cells in dense tissues, which otherwise get trapped in the matrix because of limited nuclear deformability. A digest-on-demand response has been identified, which requires nucleus-microtubule linkage through the LINC complex and triggers MT1-MMP surface-exposure to facilitate nucleus movement.
PMID: 30573318 [PubMed - as supplied by publisher]

Source: Trends in Cell Biology - December 17, 2018 Category: Cytology Authors: Ferrari R, Infante E, Chavrier P Tags: Trends Cell Biol Source Type: research