Inferring biallelism of two FSH receptor mutations associated with spontaneous ovarian hyperstimulation syndrome by evaluating FSH, LH and hCG cross-activity

ConclusionsIn vitro data support that, in the sOHSS pregnant patient, the two FSHR mutations have opposite effect on sOHSS pathogenesis and were in the biallelic heterozygous form, allowing p.Ser128Tyr FSHR-mediated cAMP increase by hCG.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research