Monoallelic MUTYH carrier status is not associated with increased breast cancer risk in a multigene panel cohort
This study aimed to determine if monoallelicMUTYH mutations are associated with increased breast cancer risk in women undergoing multigene panel testing (MGPT). The prevalence of monoallelicMUTYH mutations was compared between Non-Hispanic white female breast cancer cases (n = 30,456) and cancer-free controls (n = 12,289), all of whom underwent MGPT that includedMUTYH. We tested breast cancer associations withMUTYH alleles using Fisher ’s exact test, followed by multivariate logistic regression adjusted for age at testing and MGPT type ordered. Frequencies of the two most commonMUTYH founder mutations, p.G396D and p.Y179C, were compared independently between the breast cancer cases and MGPT controls, as well as the healthy UK10K control population (n = 2640). Comparing cases to MGPT controls, no association was observed between female breast cancer and any monoallelicMUTYH carrier status (OR 0.86 –1.36, p = 0.21–0.96). Similarly, comparisons to UK10K controls revealed no significant increase in breast cancer risk associated with p.G396D (OR 1.20, p = 0.44) or p.Y179C (OR 1.71, p = 0.24). This study did not find a significant increase in breast cancer risk associated with mono allelicMUTYH mutations.
This study, therefore, investigated the potential of two depsidones (Unguinol and Aspergillusidone D) to induce apoptosis, cell cycle arrest and cytotoxicity, and reduce cell proliferation in the triple-negative MDA-MB-231 breast cancer cell line. Results were compared with the effects of the cytostatic drug doxorubicin, antimitotic agent colchicine and endogenous hormones 17β-estradiol, testosterone and dihydrotestosterone.The cytostatic drugs and hormones affected the MDA-MB-231 cell line comparable to other studies, showing the usefulness of this model to study the effects of depsidones on a triple-negative breast ...
Publication date: Available online 21 October 2019Source: Genes &DiseasesAuthor(s): Nidhi Jain SinghaiAbstractThe breast cancer is one of the most common cancer affecting millions of lives worldwide. Though the prevalence of breast cancer is worldwide; however, the developing nations are having a comparatively higher percentage of breast cancer cases and associated complications. The molecular etiology behind breast cancer is complex and involves several regulatory molecules and their downstream signaling. Studies have demonstrated that the CD44 remains one of the major molecule associated not only in breast cancer but...
Conditions: Anesthesia; Analgesia; Acute Pain; Chronic Pain; Pectoralis Nerve Block; Erector Spine Plane Block; Patient Controlled Analgesia Interventions: Procedure: Pectoralis nerve block; Procedure: Erector spine plane block; Other: Control Sponsors: Ondokuz Mayıs University; CENGİZ KAYA (ckaya) Recruiting
Conditions: Metastatic Breast Cancer; Triple Negative Breast Cancer; Hormone Receptor Positive Tumor Interventions: Drug: Talazoparib; Drug: ASTX727 Sponsors: Kathy Miller; Pfizer; Astex Pharmaceuticals, Inc.; Van Andel Institute Stand Up to Cancer Team Not yet recruiting
Condition: Breast Cancer Intervention: Sponsor: Sunnybrook Health Sciences Centre Recruiting
Condition: Breast Cancer Interventions: Radiation: Partial Breast Irradiation (PBI); Drug: Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen Sponsors: Azienda Ospedaliero-Universitaria Careggi; Institut Curie; University of Florence Not yet recruiting
Condition: Physical Exercise Interventions: Other: Exercise training; Other: Control Sponsor: Universidad Europea de Madrid Not yet recruiting
His research brought an end to radical mastectomy, and he pioneered the design and implementation of large-scale multi-institutional randomized clinical trials.Medscape Medical News
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01653H, PaperYu Zhou, Huiying Xu, Hua Wang, Bang-Ce Ye Exosomes are membrane-enclosed phospholipid extracellular vesicles with a variety of tumor antigens which can be applied in the diagnosis and treatment of cancer due to the high secretion on the... The content of this RSS Feed (c) The Royal Society of Chemistry
Cell Death &Differentiation, Published online: 22 October 2019; doi:10.1038/s41418-019-0439-xCorrection to: Post-translational modification of OCT4 in breast cancer tumorigenesis