Evaluation and Validation of Sustained Upgaze Combined with the Ice-Pack Test for Ocular Myasthenia Gravis in Asians

Myasthenia gravis (MG) is an autoimmune disorder with antibodies targeted to acetylcholine receptors (AChRs) in the postsynaptic membrane [1]. Impaired neuromuscular junction transmission results in weakness of skeletal muscles [1]. Diagnostic tests for MG include single fiber electromyography [2], repetitive nerve stimulation test [3], acetylcholine receptor antibody (AChR-Ab) assay [4], rest test [5], ice-pack test [6], sleep test [7], and Tensilon ® or neostigmine test [8]. In patients with negative AChR-Ab, antibodies against muscle-specific kinase (MuSK), low-density lipoprotein receptor–related protein 4 (LRP4), cortactin, or agrin could be helpful for the diagnosis of MG [9].
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research