Neurophysiological, radiological and neuropsychological evaluation of fatigue in multiple sclerosis

Conclusion: The neuropsychological findings suggest common underlying mechanisms as well as bi-directional relationships between fatigue and each of anxiety, depression, and alexithymia. The neurophysiological findings may reflect maladaptive neuroplasticity processes and an aberrant GABAergic transmission in the generation of fatigue. The radiological findings could be interpreted in the light of the ‘dysfunctional hypertrophy’ or ‘compensatory hypertrophy’ hypotheses.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research