Surgery for traumatic fractures of the upper thoracic spine (T1-T6).

Conclusions: Surgical treatment of upper thoracic spine fractures (T1-T6), although complex, is safe and effective. Reduction and fixation of these fractures decreases the risk of further neurological complications, allows for earlier mobilization, and correlates with shorter hospital LOS and improved outcomes. PMID: 30568846 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

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Ninety percent of the applications to our Maximizing Investigators’ Research Award for Early Stage Investigators (known as the ESI MIRA program) that were submitted in October are about to undergo peer review. The remaining 10% were administratively withdrawn, mostly because the research proposed fell outside the NIGMS mission. This is comparable to the proportion that was withdrawn over the past 3 years. Withdrawn applications represent a lot of wasted time and effort on the part of affected PIs and are the source of considerable frustration. So what can you do to minimize the chance of this happening to your ES...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - Category: Biomedical Science Authors: Tags: Funding Opportunities Research Administration Early Stage Investigator Funding Policies MIRA Preparing an Application Source Type: blogs
AbstractSpinal cord injury (SCI) causes temporary disabilities or permanent effects including neuropathic pain and spastiscity. The damage often results frommechanical trauma, which in turn triggers the neuroinflammatory process. Neuroinflammation plays essential roles in the structural, biochemical, and cellular changes that take place in the spinal cord after the injury. Indeed, SCI activates many different signaling pathways that coordinate the resulting cellular responses. While neuroinflammation serves as a physiological reaction to harmful stimuli, it is clear that long-lasting inflammatory response leads to aggravat...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Publication date: Available online 9 January 2020Source: Neurochemistry InternationalAuthor(s): Tasuku Nishihara, Junya Tanaka, Keisuke Sekiya, Yuki Nishikawa, Naoki Abe, Taisuke Hamada, Sakiko Kitamura, Keizo Ikemune, Shinichiro Ochi, Mohammed E. Choudhury, Hajime Yano, Toshihiro YorozuyaAbstractChronic constriction injury of the sciatic nerve is frequently considered as a cause of chronic neuropathic pain. Marked activation of microglia in the posterior horn (PH) has been well established with regard to this pain. However, microglial activation in the anterior horn (AH) is also strongly induced in this process. Therefore...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
(The Physiological Society) New research shows how second-degree burns cause hard-to-treat chronic pain, and this understanding may be key to treating these complications, common in war veterans This research, published in Physiological Reports, suggests that burns cause changes to neurons in multiple parts of the spinal cord, even far from the injury site, which can contribute to chronic pain and other long-term complications.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract A growing body of evidence has indicated that the release of nociceptive factors, such as interleukins and chemokines, by activated immune and glial cells has crucial significance for neuropathic pain generation and maintenance. Moreover, changes in the production of nociceptive immune factors are associated with low opioid efficacy in the treatment of neuropathy. Recently, it has been suggested that CC chemokine receptor type 1 (CCR1) signaling is important for nociception. Our study provides evidence that the development of hypersensitivity in rats following chronic constriction injury (CCI) of the scia...
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
Study Design. Clinical case series. Objective. The aim of this study was to describe the treatment of aggressive vertebral hemangiomas (VHs) with neurological deficit treated with total en bloc spondylectomy (TES) in a single institute. Summary of Background Data. Despite increasing utilization of surgery to treat aggressive VHs, owing to the rarity, the diagnosis and treatment protocols of aggressive VHs are still questionable and disputable. Methods. All patients with Enneking stage 3 aggressive thoracic or lumbar VHs with neurological deficit and treated with TES from January 2005 to January 2013 were include...
Source: Spine - Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research
Publication date: Available online 7 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Shahani Noor, Joshua J. Sanchez, Melody S. Sun, Zinia Pervin, Jacob E. Sanchez, Mara A. Havard, Lauren T. Epler, Monique V. Nysus, Jeffrey P. Norenberg, Carston R. Wagner, Suzy Davies, Wagner Jennifer L, Daniel D. Savage, Lauren L. Jantzie, Nikolaos Mellios, Erin.D. MilliganAbstractPrevious reports show that moderate prenatal alcohol exposure (PAE) poses a risk factor for developing neuropathic pain following adult-onset peripheral nerve injury in male rats. Recently, evidence suggests that immune-related mechanisms underlying ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Abstract Previous reports show that moderate prenatal alcohol exposure (PAE) poses a risk factor for developing neuropathic pain following adult-onset peripheral nerve injury in male rats. Recently, evidence suggests that immune-related mechanisms underlying neuropathic pain in females are different compared to males despite that both sexes develop neuropathy of similar magnitude and duration following chronic constriction injury (CCI) of the sciatic nerve. Data suggest that the actions of peripheral T cells play a greater role in mediating neuropathy in females. The goal of the current study is to identify specif...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Abstract BACKGROUND: Pulsed radiofrequency (PRF), as a non-invasive treatment of neuropathic pain (NP), has been widely administered clinically. Previous studies have shown that PRF has the potential to improve hyperalgesia in animal models of NP. However, there have been few reports to clarify whether the mechanism of PRF treatment of NP involves intervention in the expression of substance P (SP). Therefore, this study administered PRF treatment to chronic constriction injury (CCI) model rats and observed the sciatic nerve mechanical pain threshold and SP expression in the spinal cord to explore the mechanism of ...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
AbstractSpinal cord injury (SCI) is  a deliberating disorder with impairments in locomotor deficits and incapacitating sensory abnormalities.Harpagophytum procumbens (Hp) is a botanical widely used for treating inflammation and pain related to various inflammatory and musculoskeletal conditions. Using a modified rodent contusion model of SCI, we explored the effects of this botanical on locomotor function and responses to mechanical stimuli, and examined possible neurochemical changes associated with SCI-induced allodynia. Following spinal cord contusion at T10 level, Hp (300  mg/kg, p.o.) or vehicle (water) was ...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research
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