Azole resistance of Malassezia pachydermatis causing treatment failure in a dog

Publication date: Available online 21 December 2018Source: Medical Mycology Case ReportsAuthor(s): Martina Angileri, Mario Pasquetti, Michela De Lucia, Andrea PeanoAbstractA 5-year-old neutered female toy Poodle chronically treated with systemic and topical azoles to control recurrent Malassezia dermatitis/otitis was presented because of the loss of treatment efficacy. Minimum Inhibitory Concentrations (MICs) obtained in vitro for various azoles (especially itraconazole and ketoconazole) against Malassezia strains isolated from the dog were increased by several-fold compared with MICs obtained for control isolates. These results reinforced the assumption based on clinical observation, i.e. the development of azole resistance
Source: Medical Mycology Case Reports - Category: Biology Source Type: research