Pre-medications for cetuximab induced infusion reactions – Commentary

We read with great interest the recent work by Touma and colleagues evaluating the role of additional pre-medications to mitigate cetuximab-related hypersensitivity reactions (HSR) [1]. Their results suggest the addition of dexamethasone, albuterol and famotidine to diphenhydramine prior to cetuximab reduces the incidence of overall as well as high-grade HSR. This finding is in agreement with a retrospective analysis of the MABEL trial, which indicated that dexamethasone as a premedication reduced the rate of HSR [2].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Letter to the editor Source Type: research