Effect of single-dose ibuprofen on follicular fluid levels of interleukins in poor responders undergoing in vitro fertilization.

In conclusion, our data show that one dose of ibuprofen administered orally the day after trigger injection revealed a significant impact on the FF inflammatory milieu. Abbreviations: IVF: in vitro fertilization; MMP: matrix metalloproteinase; IL: interleukins; FF: follicular fluid; VEGF: vascular endothelial growth factor; NSAIDS: non-steroidal anti-inflammatories; POR: poor ovarian response; AMH: anti-Mullerian hormone; TAFC: total antral follicle count; HMG: human menopausal gonadotropin; hCG: human chorionic gonadotropin; COX: cyclooxygenase enzymes; PGH2: prostaglandin H2; RANTES: regulated on activation, normal T expressed and secreted; NF-κb: nuclear factor kappa-light-chain-enhancer of activated B cells. PMID: 30571152 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30571152?dopt=Abstract

Source: Systems Biology in Reproductive Medicine - December 20, 2018 Category: Reproduction Medicine Authors: Bou Nemer L, Shi H, Carr BR, Word RA, Bukulmez O Tags: Syst Biol Reprod Med Source Type: research