Inflammatory markers predict insulin sensitivity in active rheumatoid arthritis but not in psoriatic arthritis.

Inflammatory markers predict insulin sensitivity in active rheumatoid arthritis but not in psoriatic arthritis. Reumatismo. 2018 Dec 20;70(4):232-240 Authors: Bellan M, Bor S, Gibbin A, Gualerzi A, Favretto S, Guaschino G, Bonometti R, Rossini A, Sola D, Pedrazzoli R, Carnevale Schianca GP, Pirisi M, Sainaghi PP Abstract Whether the insulin resistance commonly observed in patients with inflammatory arthritis is a disease-specific feature and/or is limited to a disease phase (i.e., it occurs only during phases of high disease activity) is unknown. Fifty-three rheumatoid arthritis (RA) and 44 psoriatic arthritis (PsA) patients were recruited consecutively along with 194 controls matched for age, sex and body mass index for a case-control study. All underwent an oral glucose tolerance test, the results of which were analysed to derive the following indexes: homeostatic model of insulin resistance (HOMA-IR), insulin sensitivity index (ISI) and early insulin sensitivity index (EISI). These data were related to anthropometric, clinical and laboratory findings. Metabolic parameters of patients and controls were similar. Neither inflammatory markers nor disease activity scores were related to glucose metabolism for the generality of RA and PsA patients; however, by restricting the analysis to the subset of RA patients with residual disease activity, an association emerged between erythrocyte sedimentation rate, on the one hand, and fasting i...
Source: Reumatismo - Category: Rheumatology Authors: Tags: Reumatismo Source Type: research