Colorectal cancer: role of imaging in screening.

[Colorectal cancer: role of imaging in screening]. Radiologe. 2018 Dec 18;: Authors: Mang T Abstract CLINICAL PROBLEM: Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality. Most colorectal cancers derive from benign precursor lesions, so-called adenomatous polyps, over a long period of time. Colorectal cancer screening is based on the detection of precancerous polyps and early stage CRC in asymptomatic individuals to reduce CRC incidence and mortality. The protective effect of screening programs can be improved by increasing the screening rates. PRACTICAL RECOMMENDATIONS: Apart from the established examinations, CT colonography (CTC) has been proposed as an optional test for colorectal cancer screening. The detection rates of CTC for large polyps and cancer are similar to the ones of colonoscopy and superior to stool-based tests. CTC is therefore the radiological test of choice for the detection of colorectal neoplasia. It has replaced double contrast barium enema for almost all indications. As a minimally invasive procedure, CTC has a high safety profile and good patient acceptance. The evaluation of extracolonic organs in addition to the colon can increase examination efficacy. The option to choose CTC as a CRC screening test has the potential to increase the overall screening rates. PMID: 30564957 [PubMed - as supplied by publisher]
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research

Related Links:

Supplementation with phytoestrogens and insoluble fibers has been reported to reduce duodenal polyps in colectomized familial adenomatous polyposis patients, with a mechanism involving, at least in part, upregulation of estrogen receptor-β subtype, whose expression is lowered during intestinal tumorigenesis. These data suggest a protective effect also in the colon, the main target organ for tumorigenesis in familial adenomatous polyposis and a major cancer type in non-familial (sporadic) cancers. Therefore, we tested whether a similar preparation might reduce tumorigenesis in the colon of Pirc rats (F344/NTac-Apcam113...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Gastrointestinal Cancer Source Type: research
Mast cells constitutively express ß-catenin and expand in solid tumors such as colon and skin cancer. However, the role of ß-catenin signaling in mast cells and the cause or effect of mast cell expansion and tumor growth has yet to be established. In earlier studies we used mast cell depletion and protease staining approaches, to provide evidence for a causative role of mast cells in small bowel polyposis, and related specific phenotypes and distributions of tumor infiltrating mast cells to stages of tumor growth. Here we report that, stabilization of ß-catenin expands mast cells to promote high incidence...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study sought to evaluate short-term treatment with COX-2 inhibitors and acute changes in colonic PGE2 levels as predictors of long-term efficacy in a genetic model of colorectal cancer.MethodsCelecoxib oral suspension (40 mg/kg BID) was dosed to Apc-mutant Pirc (F344/NTac-Apcam1137) rats for 4 days (short-term group), or the equivalent dose of 1500 ppm celecoxib was administered in the diet for 4 months (long-term group). Percent inhibition of colonic PGE2 was calculated, and the reduction in colonic PGE2 was assessed in relation to suppression of adenomatous colon polyps.ResultsColonic mucosa PGE2 was fourfold higher...
Source: Inflammation Research - Category: Research Source Type: research
Authors: Takahashi M, Fujii G, Hamoya T, Kurokawa Y, Matsuzawa Y, Miki K, Komiya M, Narita T, Mutoh M Abstract It has been reported that activation of NF-E2 p45-related factor-2 (NRF2), a transcription factor, induces a variety of antioxidant enzymes, and plays an important role in preventing carcinogenesis. AHCC is a standardized extract of cultured Lentinula edodes mycelia and it has been demonstrated to improve cancer. However, the effects of AHCC on NRF2 have not been examined, and the effects on intestinal adenoma development are not yet fully understood. We first investigated the effects of AHCC (1-5 mg/...
Source: Journal of Clinical Biochemistry and Nutrition - Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research
el Rueda Yolanda Rodríguez Jessica Pérez-García Susana Olmedillas-López Damián García-Olmo Giulia Martina Cavestro Miguel Urioste Ajay Goel Rogelio González-Sarmiento Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conclusion In a randomized controlled trial comparing AC to CAC and SC, neither device conferred additional benefits in ADR among high detectors. When comparing each device, EAC may be better than CAC at detecting more total adenomas. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
In a trial results published in JAMA Oncology, researchers at the T.H. Chan School of Public Health at Harvard found that adding 1 gram per day of omega-3s fish oils failed to reduce development of colon polyps.
Source: Health News - - Category: Consumer Health News Source Type: news
ConclusionAmong patients under age 50, advanced adenomas and ≥ 10-mm serrated polyps were predominantly in the distal colorectum. Advanced adenomas tended to be found in patients aged 45–49. Our results might explain the rising trend of distal colorectal cancer and emphasize the necessity for colonoscopy screening among these populations.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionPatients with attenuated familial adenomatous polyposis (
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Spoiler: Medically graphic image of colon A 17-year-old male is referred for colorectal cancer screening following his father’s diagnosis of metastatic colorectal cancer at the age of 47. He is asymptomatic and otherwise well. Colonoscopy reveals hundreds of adenomatous polyps throughout the colon, and he eventually undergoes a total proctocolectomy with ileal pouch anal anastomosis. Which of the following extracolonic... What malignancy is this patient at risk for?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Educational Quizzes and Case Studies Forum Source Type: forums
More News: Barium Enema | Cancer | Cancer & Oncology | Colon Cancer | Colonoscopy | Colorectal Cancer | Gastrointestinal Polyps | Polyps | Radiology