Defective collagen binding and increased bleeding in a murine model of von Willebrand disease affecting collagen IV binding.

Conclusions These results show that a decrease in the ability of 1399H VWF to bind collagen IV under static conditions corresponds to a decrease in binding under flow conditions, an increased bleeding time, and a prolonged time to thrombosis. This study supports the potential for a bleeding phenotype in patients with aberrant VWF-collagen IV binding. PMID: 30565388 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30565388?dopt=Abstract

Source: Thrombosis and Haemostasis - December 18, 2018 Category: Hematology Authors: Slobodianuk TL, Kochelek C, Foeckler J, Kalloway S, Weiler H, Flood VH Tags: J Thromb Haemost Source Type: research