Anticoagulant activity of enoxaparin and unfractionated heparin for venous thromboembolism prophylaxis in obese patients undergoing sleeve gastrectomy

While bariatric surgical procedures have shown improvements in safety, the mitigation of venous thromboembolism (VTE) risk and iatrogenic events associated with anticoagulant chemoprophylaxis requires further investigation. Obesity is a significant risk factor for VTE development and the proposed mechanisms include increased inflammation [1], increased thrombin generation [2], and greater platelet reactivity compared to individuals without obesity [3,4]. Chemoprophylaxis has been shown to reduce VTE risk, but also increases bleeding risk, complicating surgery and increase transfusion requirements [5].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research