Patients with Chronic Liver Disease Suggestive of Nonalcoholic Fatty Liver Disease may be at Higher Risk for Drug Induced Liver Injury
Authors: Dong Y, Li G Abstract Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease in developed countries and is associated with type 2 diabetes mellitus, obesity, hypertension, dyslipidemia, and metabolic syndrome. It is defined as steatosis in over 5% of hepatocytes. The disease spectrum of NAFLD ranges from simple fatty liver to nonalcoholic steatohepatitis, liver fibrosis, even hepatic cirrhosis. The disease affects various extra-hepatic systems such as the cardiovascular system and urinary system. Heart-related disease is identified as the leading cause of mor...
Publication date: Available online 20 September 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Arka De, Ajay DusejaAbstractThe histological spectrum of non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis or non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), NASH related cirrhosis and hepatocellular carcinoma (HCC). Ballooning degeneration of hepatocytes with or without fibrosis is the key-feature which differentiates NASH from NAFL. Liver biopsy is the only reliable method for diagnosing NAFL and differentiating it from NASH. Although the epidemiology of NAFL...
ConclusionHCV treatment in a large community-based cohort demonstrated sustained improvements in AST, ALT, PLT, and FIB-4. Rebound increases in AST, ALT, and FIB-4 observed in Hispanics and those with BMI>30 kg/m2 may reflect persisting nonalcoholic fatty liver disease.
Publication date: Available online 20 September 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Nikhil Makhija, Naval K. Vikram, Gurdeep Kaur, Raju Sharma, Deep N. Srivastava, Kumble S. MadhusudhanAbstractAimTo study the role of Magnetic Resonance Imaging (MRI) in monitoring hepatic fat content in cases of Non Alcoholic Fatty Liver Disease (NAFLD).Materials and methods41 adults (mean age: 39 years, 22 males; 19 females) of NAFLD were included after obtaining approval from Institutional Ethics Committee. The baseline clinical (weight, body mass index (BMI)) and biochemical parameters, fatty liver grade...
Conclusion The present study showed that high plasma glucose levels and severe liver fibrosis stage influence insulin secretion levels in Japanese patients with NAFLD. Conservation of delayed insulin secretion levels was confirmed in patients with severe liver fibrosis. PMID: 31534089 [PubMed - as supplied by publisher]
CONCLUSION: Serum Fetuin-B was positively associated with ba-PWV and may link liver fat accumulation to subclinical atherosclerosis via insulin resistance. PMID: 31527322 [PubMed - as supplied by publisher]
Conclusion: Circulating miRNAs, especially miR-122, might be promising diagnostic biomarkers for NAFLD with high-accuracy, and more large-sample studies are required to support the above findings in the future. PMID: 31531307 [PubMed - in process]
An artificial intelligence (AI) algorithm was able to automatically quantify...Read more on AuntMinnie.comRelated Reading: Ultrasound useful for evaluating liver steatosis MRI offers view of liver fat loss in obese patients Ultrasound options abound for diagnosing liver disease AIUM: Can deep learning classify liver fibrosis on US? Fatty liver disease occurs with risky plaque
CONCLUSION: Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. PMID: 31528245 [PubMed]