Lifetime major depression and grey-matter volume

Conclusion: Major depressive disorder was associated with persistent volume reductions in the deep nuclei and insula and with enlargements in visual cortex subregions; alterations varied according to age of onset and genotype. PMID: 30565905 [PubMed - in process]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

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Feixia Zheng1*, Xiuyun Ye1, Xulai Shi1, Zhongdong Lin1, Zuqin Yang1 and Longxiang Jiang2* 1Department of Pediatrics, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China 2Department of Respiratory Medicine, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China Background: Hyponatremia has frequently been described as a common complication associated with bacterial meningitis, though its frequency and clinical course in children with bacterial meningitis are unclear. The present study aimed to investigate the frequen...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This article highlights some of these challenges in the design of lifestyle studies in PD, and suggests a more coordinated international effort is required, including ongoing longitudinal observational studies. In combination with pharmaceutical treatments, healthy lifestyle behaviors may slow the progression of PD, empower patients, and reduce disease burden. For optimal care of people with PD, it is important to close this gap in current knowledge and discover whether such associations exist. Introduction Parkinson's disease (PD) is an age-related complex progressive neurodegenerative disorder, with key p...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Rui Yan1, ShiWan Tao1, HaiYan Liu1, Yu Chen1, JiaBo Shi1, YuYin Yang1, RongXin Zhu1, ZhiJian Yao1,2* and Qing Lu3,4*1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China2Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing, China3School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China4Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing, ChinaBackground: Major depressive disorders often involve somatic symptoms and have been found to have fundamental differences from non-somatic depressi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Fernando Zanela Areas1,2, Marcelo Liborio Schwarzbold1,2,3,4, Alexandre Paim Diaz1,4, Igor Kunze Rodrigues3,5,6, Daniel Santos Sousa3,7, Camila Leite Ferreira8, João Quevedo8,9, Katia Lin1,3,10, Emil Kupek3,11, Cristiane Ritter12,13, Felipe Dal Pizzol3,12,13 and Roger Walz1,2,3,10* 1Centro de Neurociências Aplicadas, Universidade Federal de Santa Catarina, Hospital Universitário, Florianópolis, Brazil 2Programa de Pós-Graduação em Neurociências, UFSC, Florianópolis, Brazil 3Programa de Pós-Graduação em Ciências Médicas, ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Altered Brain Function in Drug-Naïve Major Depressive Disorder Patients With Early-Life Maltreatment: A Resting-State fMRI StudyZhexue Xu1,2†, Jing Zhang1†, Di Wang3†, Ting Wang4, Shu Zhang5, Xi Ren2, Xiaolei Zhu7, Atsushi Kamiya7, Jiliang Fang6* and Miao Qu1,2*1Department of Neurology, Xuan Wu Hospital Capital Medical University, Beijing, China2Department of Neurology, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China3Department of Clinical Psychology, Beijing Anding Hospital, Beijing, China4Nanjing Municipal Hospital of Traditional Chinese Medicine, Nanjing, China...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, we assessed the relationship of ΔHR (difference between resting HR and HRt) and recovery from SRC. Using a retrospective cohort design, we compared acutely (30 days) in RG (p = 0.01) and PG (p = 0.04). A ΔHR of ≤50 bpm on the BCTT is 73% sensitive and 78% specific for predicting prolonged recovery in concussed adolescents who were prescribed the current standard of care (i.e., cognitive and physical rest). Introduction Sport-related concussion (SRC), a type of mild traumatic brain injury (mTBI), is a significant public health concern (1, 2). Concussion is defined as reversible neurolog...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Financial compensation was related to victims' long-term severity of impairment, although some extreme cases with severe disability were granted very poor compensation. Introduction Traumatic brain injury (TBI) occurs at a high incidence with more than 50 million people sustaining a TBI each year worldwide (1). Related to this, people with TBI are frequently involved in a litigation with claim compensation proceedings because another person was partly or wholly at fault for causing the injury, in particular in the context of road traffic accidents. While lawsuits after TBI are frequent, research...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study aimed to evaluate the impact of self-construal on neurocognitive functions in older adults. A total of 86 community-dwelling older adults 60 years and older were assessed with three common self-report measures of self-construal along individualism and collectivism (IC). A cognitive battery was administered to assess verbal and non-verbal fluency abilities. Latent profile analysis (LPA) was used to categorize individuals according to IC, and one-way analyses of covariance (ANCOVA), including relevant covariates (e.g., ethnicity, gender, linguistic abilities), were used to compare neurocognitive functions between ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Certain patients who experience mild traumatic brain injury (mTBI) may be at especially increased risk for developing posttraumatic stress disorder (PTSD) or major depressive disorder (MDD) following injury, according to astudy published this week inJAMA Psychiatry.“We observed that having an antecedent mental health problem prior to TBI [traumatic brain injury] was an exceptionally strong risk factor for having PTSD or MDD postinjury,” wrote author Murray B. Stein, M.D., M.P.H., of the University of California, San Diego and colleagues. “[T]his finding underscores the importance of clinicians being aware...
Source: Psychiatr News - Category: Psychiatry Tags: assault brain emergency department injury intervention JAMA Psychiatry mental health status mTBI Murray Stein surveillance violence Source Type: research
This study enrolled 4749 (9.5%) patients first diagnosed as having dementia. Aged, female, urban residence, and low income were found as independent sociodemographic risk factors for dementia. Among all odds ratios (ORs) of 2-comorbidity risk factors for dementia, comorbid depression and vascular disease had the highest adjusted OR of 6.726. The 5-comorbidity risk factors, namely depression, vascular disease, severe head injury, hearing loss, and DM, exhibited the highest OR of 8.767. Overall, the quantitative effects of 2 to 6 comorbidities and age difference on dementia gradually increased; hence, their ORs were less tha...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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