Meiotic spindle assembly checkpoint and aneuploidy in males versus females.

Meiotic spindle assembly checkpoint and aneuploidy in males versus females.
Cell Mol Life Sci. 2018 Dec 18;:
Authors: Lane S, Kauppi L
Abstract
The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.
PMID: 30564841 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - December 18, 2018 Category: Cytology Authors: Lane S, Kauppi L Tags: Cell Mol Life Sci Source Type: research