Dietary Oxalate and Kidney Stone Formation.

Dietary Oxalate and Kidney Stone Formation. Am J Physiol Renal Physiol. 2018 Dec 19;: Authors: Mitchell T, Kumar P, Reddy T, Wood KD, Knight J, Assimos DG, Holmes RP Abstract Dietary oxalate is plant derived and may be a component of vegetables, nuts, fruits and grains. In normal individuals, approximately half of urinary oxalate is derived from the diet and half from endogenous synthesis. The amount of oxalate excreted in urine plays an important role in calcium oxalate (CaOx) stone formation. Large epidemiologic cohort studies have demonstrated that urinary oxalate excretion is a continuous variable when indexed to stone risk. Thus, those with oxalate excretions greater than 25 mg/day may benefit from a reduction in urinary oxalate output. The 24 hour urine assessment may miss periods of transient surges in urinary oxalate excretion which may promote stone growth, a limitation of this analysis. In this review, we describe the impact of dietary oxalate and its contribution to stone growth. To limit CaOx stone growth, we advocate that patients maintain appropriate hydration, avoid oxalate-rich foods, and consume an adequate amount of calcium. PMID: 30566003 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research