Experimental Alzheimer ’s drug improves memory in mice

FINDINGSAn experimental drug known as A03, which was previously developed to treat depression, increases the levels of the enzyme Sirtuin1, or SirT1, and improves memory in mice. The mice were genetically modified to have a protein called ApoE4, the most common genetic risk factor for Alzheimer ’s disease in humans that has been linked to some forms of the disease.BACKGROUNDMore than 10 percent of the general population has the ApoE4 gene variant, which increases the likelihood that they will develop Alzheimer ’s disease. About two in three people with Alzheimer’s have that variant. Previous research has found that the ApoE4 variant lowers levels of SirT1, which promotes the health of brain cells. Increasing levels of SirT1 in those predisposed to or with the disease, researchers have hypothesized, ma y delay the onset of symptoms and the buildup of a toxic protein known as tau. This results in improved cognition in Alzheimer’s patients.METHODResearchers at UCLA ’s Drug Discovery Lab first identified A03 while screening a large library of drug compounds for their ability to increase levels of SirT1 in the presence of ApoE4. When they treated the ApoE4 model mice with A03 for 56 days, they observed increased levels of SirT1 in the hippocampi of mice — a key area of the brain affected in Alzheimer’s. The mice also showed improvement on memory tests.IMPACTAn estimated 5.7 million Americans have Alzheimer ’s disease and there is currently no cure or effective trea...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news